J Korean Med Sci.  2013 Oct;28(10):1431-1434. 10.3346/jkms.2013.28.10.1431.

Patients with Persistent New-Onset Diabetes after Transplantation Have Greater Weight Gain after Kidney Transplantation

  • 1Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. wooseong.huh@samsung.com
  • 2Department of Clinical Pharmacology and Therapeutics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
  • 3Department of Medicine, Konkuk University Chungju Hospital, Chungju, Korea.
  • 4Department of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
  • 5Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.


The purpose of the present study was to evaluate the difference in BMI pattern between patients with persistent new-onset diabetes after transplantation (P-NODAT) and without new-onset diabetes after transplantation (N-NODAT) in a retrospective matched case-control (1:3) analysis. Thirty-six patients who developed P-NODAT were identified among 186 adult renal transplant recipients with no evidence of pretransplant diabetes mellitus who underwent kidney transplantation from September 1997 to March 2008 and were treated with a triple regimen including tacrolimus. The controls were selected to match the patients for pretransplant BMI, age at transplantation (+/- 5 yr), and date of transplantation (+/- 12 months). Finally, 20 P-NODAT patients and 60 N-NODAT patients were selected. The pre- and posttransplant BMI data were collected every 16 weeks for up to 80 weeks. The clinical characteristics did not differ between the P-NODAT group and N-NODAT group. BMI increased faster in the P-NODAT group than in the N-NODAT group. The mixed-model analysis showed that patients with P-NODAT exhibited a faster increase in BMI. P-NODAT is associated with posttransplant weight gain. The risk of P-NODAT should be considered in patients with rapid weight gain after transplantation.


Transplantation; Diabetes Mellitus; Obesity

MeSH Terms

Body Mass Index
Case-Control Studies
Diabetes Mellitus, Type 2/*etiology
Graft Rejection/prevention & control
Immunosuppressive Agents/therapeutic use
*Kidney Transplantation
Middle Aged
Retrospective Studies
Tacrolimus/therapeutic use
Time Factors
*Weight Gain
Immunosuppressive Agents


  • Fig. 1 Estimated marginal means for BMI over time analyzed according to the presence or absence of P-NODAT (adjusted for baseline BMI of 23.384 kg/m2). Bars represent standard errors.


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