J Korean Med Sci.  2013 Oct;28(10):1431-1434. 10.3346/jkms.2013.28.10.1431.

Patients with Persistent New-Onset Diabetes after Transplantation Have Greater Weight Gain after Kidney Transplantation

• Kim Y
• Kim JR
• Choi H
• Hwang JW
• Jang HR
• Lee JE
• Kim SJ
• Kim YG
• Kim DJ
• Oh HY
• Huh W

• KMID: 1777677
• DOI: http://doi.org/10.3346/jkms.2013.28.10.1431

Abstract

The purpose of the present study was to evaluate the difference in BMI pattern between patients with persistent new-onset diabetes after transplantation (P-NODAT) and without new-onset diabetes after transplantation (N-NODAT) in a retrospective matched case-control (1:3) analysis. Thirty-six patients who developed P-NODAT were identified among 186 adult renal transplant recipients with no evidence of pretransplant diabetes mellitus who underwent kidney transplantation from September 1997 to March 2008 and were treated with a triple regimen including tacrolimus. The controls were selected to match the patients for pretransplant BMI, age at transplantation (+/- 5 yr), and date of transplantation (+/- 12 months). Finally, 20 P-NODAT patients and 60 N-NODAT patients were selected. The pre- and posttransplant BMI data were collected every 16 weeks for up to 80 weeks. The clinical characteristics did not differ between the P-NODAT group and N-NODAT group. BMI increased faster in the P-NODAT group than in the N-NODAT group. The mixed-model analysis showed that patients with P-NODAT exhibited a faster increase in BMI. P-NODAT is associated with posttransplant weight gain. The risk of P-NODAT should be considered in patients with rapid weight gain after transplantation.

Keyword

Transplantation; Diabetes Mellitus; Obesity

MeSH Terms

Adult
Body Mass Index
Case-Control Studies
Diabetes Mellitus, Type 2/*etiology
Female
Graft Rejection/prevention & control
Humans
Immunosuppressive Agents/therapeutic use
*Kidney Transplantation
Male
Middle Aged
Retrospective Studies
Tacrolimus/therapeutic use
Time Factors
*Weight Gain
Immunosuppressive Agents
Tacrolimus

Figure

• 

  Fig. 1 Estimated marginal means for BMI over time analyzed according to the presence or absence of P-NODAT (adjusted for baseline BMI of 23.384 kg/m2). Bars represent standard errors.

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