Korean J Intern Med.  2007 Dec;22(4):296-299. 10.3904/kjim.2007.22.4.296.

Duodenal Mucosa-Associated Lymphoid Tissue Lymphoma: A Case Report

• Woo KH
• Kim JH
• Yoon SB
• Jang JH
• Lee DH
• Hong SH
• Baek IH

• KMID: 1776685
• DOI: http://doi.org/10.3904/kjim.2007.22.4.296

Abstract

Primary duodenal mucosa associated lymphoid tissue (MALT) lymphoma is very rare, and little is known about its clinical course or effective treatment. We describe a case of primary duodenal MALT lymphoma that was resistant to Helicobacter pylori (H. pylori) eradication and regressed after chemotherapy with cyclophosphamide, vincristine, and prednisolone (CVP). A 71-year-old woman was referred to our department because of epigastric pain and dyspepsia. Gastroduodenoscopy revealed an irregular mucosal nodular lesion with ulceration extending from the bulb to the second portion of the duodenum. Histopathological examination of a biopsy specimen disclosed low-grade MALT lymphoma composed of atypical lymphoid cells with lymphoepithelial lesion. Abdominal CT scans revealed 0.5 to 1.5 cm lymph nodes in the peritoneal cavity, suggestive of lymph node metastasis. We successfully eradicated H. pylori but did not see signs of remission. We administered systemic CVP chemotherapy every 3 weeks. After 6 courses of CVP, the patient achieved complete remission and was followed up without recurrence for about a year.

Keyword

MALT lymphoma; Duodenum; Helicobacter pylori; Chemotherapy

MeSH Terms

Aged
Antineoplastic Protocols
Cyclophosphamide
Duodenum/*pathology
Female
Helicobacter Infections
Humans
Lymphoma, B-Cell, Marginal Zone/diagnosis/*pathology
Prednisolone
Vincristine