Korean J Intern Med.  2012 Mar;27(1):66-71. 10.3904/kjim.2012.27.1.66.

Associations among Body Mass Index, Insulin Resistance, and Pancreatic beta-Cell Function in Korean Patients with New-Onset Type 2 Diabetes

• Chung JO
• Cho DH
• Chung DJ
• Chung MY

• KMID: 1776568
• DOI: http://doi.org/10.3904/kjim.2012.27.1.66

Abstract

BACKGROUND/AIMS
We investigated the associations among body mass index (BMI), insulin resistance, and beta-cell function in Korean patients newly presenting with type 2 diabetes.
METHODS
In total, 132 patients with new-onset type 2 diabetes mellitus were investigated. A standard 75-g oral glucose tolerance test was performed, and the indices of insulin secretion and insulin resistance were calculated.
RESULTS
A higher BMI was associated with higher homeostasis model assessment values for insulin resistance (HOMA-IR), homeostasis model assessment of beta-cell function (HOMA-beta), and insulinogenic index as well as lower levels of insulin sensitivity index composite (ISIcomp) and disposition index (DI). In multiple regression models, BMI had independent positive associations with HOMA-IR, ISIcomp, and HOMA-beta and inverse associations with the DI.
CONCLUSIONS
Our results showed that BMI had independent positive associations with indices of insulin resistance and an inverse association with beta-cell function adjusted for insulin resistance in Korean patients newly presenting with type 2 diabetes.

Keyword

Body mass index; Insulin resistance; Secretion; Diabetes mellitus, type 2

MeSH Terms

*Asian Continental Ancestry Group
Biological Markers/blood
Blood Glucose/metabolism
*Body Mass Index
Diabetes Mellitus, Type 2/blood/diagnosis/*ethnology/physiopathology
Female
Glucose Tolerance Test
Hemoglobin A, Glycosylated/metabolism
Humans
Insulin/blood
Insulin Resistance/*ethnology
Insulin-Secreting Cells/*metabolism
Linear Models
Logistic Models
Male
Middle Aged
Multivariate Analysis
Predictive Value of Tests
Republic of Korea/epidemiology
Risk Assessment
Risk Factors