- Role of autophagy in diabetes and endoplasmic reticulum stress of pancreatic beta-cells
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Quan W, Lim YM, Lee MS
- KMID: 1120126
- Exp Mol Med.
- 2012 Feb;44(2):81-88.
- doi: 10.3858/emm.2012.44.2.030
Type 2 diabetes mellitus is characterized by insulin resistance and failure of pancreatic beta-cells producing insulin. Autophagy plays a crucial role in cellular homeostasis through degradation and recycling of organelles... -
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- Associations among Body Mass Index, Insulin Resistance, and Pancreatic beta-Cell Function in Korean Patients with New-Onset Type 2 Diabetes
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Chung JO, Cho DH, Chung DJ, Chung MY
- KMID: 1776568
- Korean J Intern Med.
- 2012 Mar;27(1):66-71.
- doi: 10.3904/kjim.2012.27.1.66
BACKGROUND/AIMS: We investigated the associations among body mass index (BMI), insulin resistance, and beta-cell function in Korean patients newly presenting with type 2 diabetes. METHODS: In total, 132 patients with new-onset... -
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- Transplantation of betacellulin-transduced islets improves glucose intolerance in diabetic mice
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Song MY, Bae UJ, Jang KY, Park BH
- KMID: 2155363
- Exp Mol Med.
- 2014 May;46(5):e98.
- doi: 10.1038/emm.2014.24
Type 1 diabetes is an autoimmune disease caused by permanent destruction of insulin-producing pancreatic beta cells and requires lifelong exogenous insulin therapy. Recently, islet transplantation has been developed, and although... -
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- Rac-mediated actin remodeling and myosin II are involved in KATP channel trafficking in pancreatic beta-cells
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Han YE, Lim A, Park SH, Chang S, Lee SH, Ho WK
- KMID: 2160621
- Exp Mol Med.
- 2015 Oct;47(10):e190.
- doi: 10.1038/emm.2015.72
AMP-activated protein kinase (AMPK) is a metabolic sensor activated during metabolic stress and it regulates various enzymes and cellular processes to maintain metabolic homeostasis. We previously reported that activation of... -
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- Parameters Measuring Beta-Cell Function Are Only Valuable in Diabetic Subjects with Low Body Mass Index, High Blood Glucose Level, or Long-Standing Diabetes
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Lee SW, Lee S, Kim SH, Kim TH, Kang BS, Yoo SH, Lee MK, Koh WJ, Kang WS, Kim HJ
- KMID: 1058813
- Yonsei Med J.
- 2011 Nov;52(6):939-947.
- doi: 10.3349/ymj.2011.52.6.939
PURPOSE: The aim of this study was to identify the most precise and clinically practicable parameters that predict future oral hypoglycemic agent (OHA) failure in patients with type 2 diabetes,... -
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