Korean J Gastroenterol.  2010 Mar;55(3):194-197. 10.4166/kjg.2010.55.3.194.

A Case of Non-occulsive Mesentery Ischemia with Pulmonary Embolism due to Protein C Deficiency

• Kim TW
• Choi SY
• Kang IJ
• Kang YJ
• Shin DH

• KMID: 1775902
• DOI: http://doi.org/10.4166/kjg.2010.55.3.194

Abstract

Protein C is an important physiological anticoagulant factor. Protein C deficiency has been linked to venous thrombosis at unusual sites, including the cerebral and mesenteric veins. Hereditary protein C deficiency is inherited primarily as an autosomal dominant trait with incomplete penetrance. Protein C and S deficiencies are known to increase the risk of venous thrombosis and pulmonary thromboembolism. Testing for protein C levels and function is necessary for the detection of both type I and type II protein C deficiency. In this article, we report a case of pulmonary embolism and mesentery ischemia due to type 1 protein C deficiency.

Keyword

Protein C deficiency; Ischemia, Mesentery; Pulmonary embolism

MeSH Terms

Colonoscopy
Humans
Ischemia/*diagnosis/etiology
Magnetic Resonance Angiography
Male
Mesenteric Veins
Middle Aged
Protein C Deficiency/*complications/genetics
Pulmonary Embolism/*diagnosis/etiology/radiography
Tomography, X-Ray Computed

Figure

• 

  Fig. 1. (A) Computed tomogram of abdomen showed dilatation of sigmoid colon associated with per-icolic fatty stranding (arrow) and small amount of fluid collection. (B) Surface rendering reconstruction image of abdomen showed no evidence of mesenteric artery occlusion.

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  Fig. 2. Chest computed tomography showed low density throm-boses in both side of main pulmonary artery (arrow) and sub-segmental artery (dotted arrow).

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  Fig. 3. Colonoscopy showed multiple linear ulcerations with edematous margin.

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