Korean J Gastroenterol.  2013 Apr;61(4):203-208. 10.4166/kjg.2013.61.4.203.

Factors Associated with Vaccination among Inflammatory Bowel Disease Patients in Korea

• Yun HS
• Min YW
• Chang DK
• Rhee PL
• Kim JJ
• Rhee JC
• Kim YH

• KMID: 1775759
• DOI: http://doi.org/10.4166/kjg.2013.61.4.203

Abstract

BACKGROUND/AIMS
Vaccinations are generally recommended in patients with inflammatory bowel disease (IBD). However, several studies showed low rates of vaccinations in IBD patients. Furthermore, vaccination rate among IBD patients in Korea has never been investigated. We investigated the vaccination rate among IBD patients in Korea and evaluated some factors that might affect the vaccination rate.
METHODS
From November 2011 to February 2012, a total of 192 patients with IBD who visited Samsung Medical Center (Seoul, Korea) answered the IRB-approved questionnaire. The questionnaire included their sex, age, residence, past medical history, type of IBD, duration of illness, medications, history of vaccination about measles-mumps-rubella (MMR), varicella, tetanus-diphtheria (Td), influenza, hepatitis A and B, pneumococcus and human papilloma virus (HPV).
RESULTS
One hundred twenty one (63.0%) male and 71 (37.0%) female answered the questionnaire. The mean age of the enrolled patients was 39.7 (18-76) years. Eighty four patients (43.8%) had ulcerative colitis and 108 patients (56.3%) had Crohn's disease (CD). The percentage of the patients who had got vaccination was 42.2% for MMR, 34.9% for varicella, 15.6% for Td, 37.5% for influenza, 15.6% for hepatitis A, 52.6% for hepatitis B, 6.3% for pneumococcus and 11.3% for HPV respectively. Not knowing the necessity or the existence were the common reasons for non-vaccination. Age less than 40 years, CD patients and duration of illness less than 10 years were associated with a higher vaccination rate (p=0.002, 0.015 and 0.020, respectively).
CONCLUSIONS
Immunization rates for recommended vaccinations were very low in patients with IBD. Efforts to improve vaccination rate are needed.

Keyword

Inflammatory bowel disease; Vaccination; Ulcerative colitis; Crohn's disease; Korea

MeSH Terms

Adolescent
Adult
Aged
Chickenpox/prevention & control
Colitis, Ulcerative/pathology
Crohn Disease/pathology
Diphtheria/prevention & control
Female
Hepatitis A/prevention & control
Hepatitis B/prevention & control
Humans
Inflammatory Bowel Diseases/*immunology/pathology
Male
Measles/prevention & control
Middle Aged
Mumps/prevention & control
Papillomavirus Infections/prevention & control
Pneumococcal Infections/prevention & control
Questionnaires
Republic of Korea
Rubella/prevention & control
Tetanus/prevention & control
*Vaccination
Young Adult

Figure

• 

  Fig. 1. Vaccination rates in regular order among inflammatory bowel disease patients in Korea. The rates of vaccinated patients were 52.6% for hepatitis B virus, 42.2% for measles-mumps-rubella (MMR), 37.5% for influenza, 34.9% for varicella, 15.6% for hepatitis A virus, 15.6% for tetanus-diphtheria (Td), 11.3% for human papilloma virus (HPV) and 6.3% for pneumococcus.

• 

  Fig. 2. The number of answers for the reasons of vaccination. The reasons for vaccination were childhood vaccination (191, 49.6%), physician's recommendation (48, 12.5%), patient's own worry about health (46, 11.9%), the guidance of institutions or organization (40, 10.4%), and etc.

• 

  Fig. 3. The number of answers for the reasons of non-vaccination. The reasons for non-vaccination were not knowing the necessity of the vaccination (144, 28.3%), not knowing the presence of the vaccine (124, 24.4%), no need because they are healthy (77, 15.0%), and etc.

Reference

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