Korean J Gastroenterol.  2012 Dec;60(6):386-390. 10.4166/kjg.2012.60.6.386.

A Case of Colloid Carcinoma Arising in Association with Intraductal Papillary Neoplasm of the Liver

• Kang GH
• Moon HS
• Lee ES
• Kim SH
• Sung JK
• Lee B
• Jeong HY

• KMID: 1773077
• DOI: http://doi.org/10.4166/kjg.2012.60.6.386

Abstract

Colloid carcinoma of the liver is very rare, and its clinicopathologic features have not been well characterized yet. We describe herein a case of colloid carcinoma of the liver. Imaging revealed a lobulated mass, measuring 12 cm in diameter at the right lobe of the liver with direct invasion of adjacent peripheral intrahepatic bile ducts. Right hemihepatectomy of the liver was performed according to the possibility of the tumor's malignant behavior. Histopathological examination of the specimen revealed large extracelluar stromal mucin pools containing floating cuboidal to columnar neoplastic cells without ovarian-like stroma. This case seemed to be colloid carcinoma arising in association with intraductal papillary neoplasm of the liver.

Keyword

Colloid carcinoma; Intrahepatic bile ducts

MeSH Terms

Adenocarcinoma, Mucinous/*diagnosis/pathology/secondary
Adenoma/*diagnosis/pathology
Aged
Bile Duct Neoplasms/*diagnosis/pathology
*Bile Ducts, Intrahepatic
Female
Humans
Liver Neoplasms/*diagnosis/pathology/secondary
Magnetic Resonance Imaging
Mucins/metabolism
Tomography, X-Ray Computed
Mucins

Figure

• 

  Fig. 1 CT revealed a lobulated mass measuring 12.0 cm in diameter at the right lobe of the liver (A) and variable sized simple cysts, largest one at the right posterosuperior segment measuring about 7.4 cm (B).

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  Fig. 2 MRI revealed a low attenuating mass as high in the T2-weighted image with mild enhancement of numerous septa and irregular large cystic portion.

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  Fig. 3 The gross appearance of the resected specimen showed well demarcated solid mucoid mass without capsule, measuring 13.0×12.0×10.0 cm in size with multiple small papillary nodules in the lumen of the bile duct.

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  Fig. 4 Microscopic findings (×40). (A) Intraductal papillary neoplasm (IPN; left side) and colloid carcinoma (CC; right side) (H&E, ×40). (B) IPN and CC showed mucin core protein (MUC) 6 positive (MUC6 immunohistochemical stain, ×40). (C) IPN and CC showed MUC5AC positive (MUC5AC immunohistochemical stain, ×40). (D) IPN and CC showed MUC2 negative (MUC2 immunohistochemical stain, ×40).

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