Korean J Anesthesiol.  2012 Oct;63(4):321-326. 10.4097/kjae.2012.63.4.321.

Comparison of clinical effects according to the dosage of sufentanil added to 0.5% hyperbaric bupivacaine for spinal anesthesia in patients undergoing cesarean section

• Bang YS
• Chung KH
• Lee JH
• Hong SK
• Choi SH
• Lee JY
• Lee SY
• Yang HJ

• KMID: 1767170
• DOI: http://doi.org/10.4097/kjae.2012.63.4.321

Abstract

BACKGROUND
Subarachnoid block is a widely used technique for cesarean section. To improve the quality of analgesia and prolong the duration of analgesia, addition of intrathecal opioids to local anesthetics has been encouraged. We compared the effects of sufentanil 2.5 microg and 5 microg, which were added to intrathecal hyperbaric bupivacaine.
METHODS
We enrolled 105 full term parturients were randomly divided into 3 groups: Group 1 (control), Group 2 (sufentanil 2.5 microg), and Group 3 (sufentanil 5 microg). In every group, 0.5% heavy bupivacaine was added according to the adjusted dose regimen. We determined the maximum level of sensory block and motor block, the quality of intraoperative analgesia, the duration of effective analgesia and side effects.
RESULTS
There were no significant differences among the 3 groups in the maximum level of the sensory block and motor block. Recovery rate of the sensory block, however, was significantly slower in Group 3 than Group 1. Quality of intraopertive analgesia, muscle relaxation, and duration of effective analgesia were enhanced by increasing the dosage of intrathecal sufentanil. Frequencies of hypotension, maximum sedation level, and pruritus were directly related to the dosage of intrathecal sufentanil, whereas nausea and vomiting occurred only in the groups using sufentanil.
CONCLUSIONS
The addition of sufentanil 2.5 microg for spinal anesthesia provides adequate intraoperative analgesia and good postoperative analgesia with minimal adverse effects on the mother.

Keyword

Bupivacaine; Cesarean section; Spinal anesthesia; Sufentanil

MeSH Terms

Analgesia
Analgesics, Opioid
Anesthesia, Spinal
Anesthetics, Local
Bupivacaine
Cesarean Section
Female
Humans
Hypotension
Mothers
Muscle Relaxation
Nausea
Pregnancy
Pruritus
Sufentanil
Vomiting
Analgesics, Opioid
Anesthetics, Local
Bupivacaine
Sufentanil