Korean J Anesthesiol.
2009 Oct;57(4):434-437. 10.4097/kjae.2009.57.4.434.
Effect of midazolam premedication on the onset of propofol and rocuronium during propofol target-controlled infusion
- Affiliations
-
- 1Department of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, Seongnam, Korea. jungwon@snubh.org
- 2Department of Anesthesiology and Pain Medicine, Seoul National University College of Medicine, Seoul, Korea.
- KMID: 1765440
- DOI: http://doi.org/10.4097/kjae.2009.57.4.434
Abstract
- BACKGROUND
This clinical study was designed to evaluate the effect of midazolam as a premedication on the onset of propofol and rocuronium during propofol target-controlled infusion (TCI).
METHODS
Seventy four patients (ASA class I or II) were randomly allocated to receive either no premedication (control group) or premedication with 0.04 mg/kg intravenous midazolam (midazolam group). Anesthesia was induced and maintained with propofol TCI. Time from propofol injection to loss of consciousness (LOC) and estimated effect concentration at LOC were recorded. After LOC, rocuronium (0.6 mg/kg) was injected. We monitored the degree of neuromuscular blockade by acceleromyography. The following parameters were measured and compared between groups: Time from rocuronium injection to depression of twitch height below 25%, time to maximal depression of twitch height (defined as rocuronium onset time). RESULTS: Systolic blood pressure before induction was lower in midazolam group (125 +/- 15 vs 135 +/- 20 mmHg), however, there was no difference in blood pressure at LOC between groups (111 +/- 16 vs 106 +/- 21 mmHg). In midazolam group, time to LOC in propofol TCI was shorter (63 +/- 22 vs. 203 +/- 118 sec) and estimated effect site concentration of propofol was significantly lower than control group (0.9 +/- 0.3 vs. 2.2 +/- 0.4 microl/ml). The onset time of rocuronium was not different between groups (120 +/- 39 vs. 137 +/- 42 sec).
CONCLUSIONS
Midazolam pretreatment fastens the onset time of propofol and decreases the propofol requirement for LOC. However, it does not influence the onset of rocuronium.
Keyword
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Hemodynamic and Auditory Evoked Potential Index Responses to Intubation during the Target-Effect Site-Controlled Infusion of Propofol
- The effects of midazolam and remifentanil on induction of anesthesia and hemodynamics during tracheal intubation under target-controlled infusion of propofol
- The Effect of Midazolam Premedication on Propofol Induction Using a Target Controlled Infusion (TCI)
- Monitored Anesthetic Care (MAC) Using Ketamine, Midazolam and a Target-Controlled Propofol Infusion for Minor Surgery
- The Frequency of Apnea and Loss of Consciousness According to Propofol Dosage in Premedicated Patients with Midazolam
