Korean J Anesthesiol.  2003 Nov;45(5):589-595. 10.4097/kjae.2003.45.5.589.

Hemodynamic and Auditory Evoked Potential Index Responses to Intubation during the Target-Effect Site-Controlled Infusion of Propofol

• Kim YJ
• Baik HJ
• Kim JH

• KMID: 1935946
• DOI: http://doi.org/10.4097/kjae.2003.45.5.589

Abstract

BACKGROUND: We evaluated the hemodynamic responses and the rapidly extracted auditory evoked potential index (A-line ARX index or AAI) responses during induction and intubation at different effect site concentration of propofol using target-controlled infusion.
METHODS
Thirty patients scheduled for elective surgery under general anesthesia were randomly assigned to 3 groups (Groups I, II, and III). Anesthesia was induced using the infusion of propofol at three different effect site concentrations as a target (Group I: 3.0microgram/ml, Group II: 3.5microgram/ml, and Group III: 4.0microgram/ml) following midazolam premedication. We measured AAI, systolic, diastolic, and mean arterial blood pressures and the heart rate after midazolam premedication, loss of consciousness, just before intubation, immediately after intubation, and 1, 2, and 3 minutes after intubation.
RESULTS
In Groups II and III, AAI were significantly lower than that in group I immediately after intubation, and % changes in diastolic and mean arterial blood pressures were significantly lower than that in group I 1 minute after intubation (P<0.05).
CONCLUSIONS
Effect site concentration of propofol targeted at 3.5microgram/ml or 4.0microgram/ml produces better hemodynamic stability and AAI responses during intubation than that achieved at 3.0microgram/ml.

Keyword

auditory evoked potential index; effect site; hemodynamic response; intubation; propofol; target-controlled infusion

MeSH Terms

Anesthesia
Anesthesia, General
Arterial Pressure
Evoked Potentials, Auditory*
Heart Rate
Hemodynamics*
Humans
Intubation*
Midazolam
Premedication
Propofol*
Unconsciousness
Midazolam
Propofol