Korean J Intern Med.  2002 Mar;17(1):69-72.

A Case of NK/T-Cell Lymphoma Complicated by a Squamous Cell Carcinoma of Hard Palate during Combination Chemotherapy and Radiation Therapy

Affiliations
  • 1Department of Internal Medicine Hanyang University College of Medicine, Seoul, Korea.
  • 2Department of Hanyang University Pathology College of Medicine, Seoul, Korea.

Abstract

NK/T-cell lymphoma, which often shows an angiocentric growth pattern, is a distinct clinicopathologic entity highly associated with Epstein-Barr virus. The disease is characterized by a destruction of the upper respiratory tract, particularly the nasal cavity, palate and paranasal sinuses. Interestingly, NK/T-cell lymphoma is closely linked to a variety of complications, such as hemophagocytic syndrome, second primary cancer, sepsis and bleeding. Here we report a case of a 50-year-old man diagnosed initially as NK/T-cell lymphoma of the oropharynx and who developed a second primary carcinoma of the hard palate during combination chemotherapy and radiation therapy.

Keyword

NK/T-cell Lymphoma; Second Primary Cancer; Squamous Cell Carcinoma; Hard Palate

MeSH Terms

Carcinoma, Squamous Cell/*pathology/therapy
Case Report
Combined Modality Therapy
Fatal Outcome
Human
Killer Cells, Natural
Lymphoma, T-Cell/*pathology/therapy
Male
Middle Age
Neoplasms, Second Primary/*pathology/therapy
Oropharyngeal Neoplasms/*pathology/therapy
Palatal Neoplasms/*pathology/therapy
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