Yonsei Med J.
1993 Dec;34(4):321-327. 10.3349/ymj.1993.34.4.321.
Nucleotide sequence analysis of HTLV-I isolate from a Korean patient with HAM/TSP
- Affiliations
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- 1Department of Cellular and Molecular Biology, Institute of Medical Science, University of Tokyo, Shirokanedai, Minatoku, Tokyo, Japan.
- 2Department of Neurology, Yonsei University College of Medicine, Seoul, Korea.
- 3Department of Internal Medicine, Faculty of Medicine, Kagoshima University, Kagoshima, Japan.
- KMID: 1758495
- DOI: http://doi.org/10.3349/ymj.1993.34.4.321
Abstract
- Limited nucleotide sequences of human T-cell lymphotropic virus type I (HTLV-1) provirus isolated from the first case of a Korean patient with HTLV-I associated myelopathy and tropical spastic paraparesis (HAM/TSP) were analysed and compared with other isolates from different regions of the world. The sequences of the env, LTR regions (536bp, 690bp respectively) showed 98.7%, 99.3% homologies with the prototype HTLV-I, ATK-1, isolated from a Japanese Adult T-cell leukemia (ATL) patient. A comparison between other isolates from different geographical origins revealed that the Korean HTLV-I isolate is more closely related to Japanese isolates than to those from other geographical origins
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