Clin Orthop Surg.  2014 Mar;6(1):20-25. 10.4055/cios.2014.6.1.20.

Osteomyelitis: A Descriptive Study

Affiliations
  • 1Department of Internal Medicine, IIS-Fundacion Jimenez Diaz, Madrid, Spain.
  • 2Department of Clinical Microbiology, IIS-Fundacion Jimenez Diaz, Madrid, Spain. ramontanoira@hotmail.com

Abstract

BACKGROUND
To analyze the incidence and clinical-microbiological characteristics of osteomyelitis (OM) in a tertiary Spanish hospital.
METHODS
All cases diagnosed with OM between January 2007 and December 2010 were retrospectively reviewed. The variables examined include epidemiological characteristics, risk factors, affected bone, radiographic changes, histology, microbiological culture results, antibiotic treatment, and the need for surgery.
RESULTS
Sixty-three cases of OM were diagnosed. Twenty-six patients (41.3%) had acute OM whereas 37 patients (58.7%) were classified as chronic OM. OM may result from haematogenous or contiguous microbial seeding. In this group, 49 patients (77.8%) presented with OM secondary to a contiguous source of infection and 14 patients had hematogenous OM (22.2%). Staphylococcus aureus was the most commonly found microorganism.
CONCLUSIONS
OM mainly affected patients with risk factors related to the presence of vascular diseases. Antibiotic treatment must be guided by susceptibility patterns of individual microorganisms, although it must be performed together with surgery in most of the cases.

Keyword

Osteomyelitis; Bone infection; Antimicrobial therapy; Staphylococcus aureus; Debridement

MeSH Terms

Acute Disease
Adolescent
Adult
Aged
Aged, 80 and over
Anti-Bacterial Agents/therapeutic use
Child
Child, Preschool
Chronic Disease
Female
Humans
Infant
Male
Middle Aged
*Osteomyelitis/drug therapy/epidemiology/microbiology
Retrospective Studies
Risk Factors
Spain/epidemiology
Staphylococcal Infections
Staphylococcus aureus/isolation & purification
Tertiary Care Centers
Young Adult
Anti-Bacterial Agents

Figure

  • Fig. 1 Age of 63 patients with osteomyelitis.

  • Fig. 2 Sites of osteomyelitis in 63 patients.


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Reference

1. Chihara S, Segreti J. Osteomyelitis. Dis Mon. 2010; 56(1):5–31. PMID: 19995624.
Article
2. Lew DP, Waldvogel FA. Osteomyelitis. Lancet. 2004; 364(9431):369–379. PMID: 15276398.
Article
3. Sia IG, Berbari EF. Infection and musculoskeletal conditions: osteomyelitis. Best Pract Res Clin Rheumatol. 2006; 20(6):1065–1081. PMID: 17127197.
4. Brady RA, Leid JG, Costerton JW, Shirtliff ME. Osteomyelitis: clinical overview and mechanisms of infection persistence. Clin Microbiol Newsl. 2006; 28(9):65–72.
Article
5. Trampuz A, Zimmerli W. Diagnosis and treatment of implant-associated septic arthritis and osteomyelitis. Curr Infect Dis Rep. 2008; 10(5):394–403. PMID: 18687204.
Article
6. Cierny G 3rd, Mader JT, Penninck JJ. A clinical staging system for adult osteomyelitis. Clin Orthop Relat Res. 2003; (414):7–24. PMID: 12966271.
7. Berbari EF, Steckelberg JM, Osmon DR. Osteomyelitis. In : Mandell GL, Bennett JE, Dolin R, editors. Mandell, Douglas, and Bennett's principles and practice of infectious diseases. 7th ed. Philadelphia, PA: Churchill Livingston;2010. p. 1457–1468.
8. Mouzopoulos G, Kanakaris NK, Kontakis G, Obakponovwe O, Townsend R, Giannoudis PV. Management of bone infections in adults: the surgeon's and microbiologist's perspectives. Injury. 2011; 42(Suppl 5):S18–S23. PMID: 22196905.
Article
9. Gentry LO. Management of osteomyelitis. Int J Antimicrob Agents. 1997; 9(1):37–42. PMID: 18611817.
Article
10. Tice AD, Hoaglund PA, Shoultz DA. Outcomes of osteomyelitis among patients treated with outpatient parenteral antimicrobial therapy. Am J Med. 2003; 114(9):723–728. PMID: 12829198.
Article
11. Maldonado-Rodríguez M, Cajigas-Feliciano Y, Torres-Torres N. Outcomes of osteomyelitis in patients with diabetes: conservative vs. combined surgical management in a community hospital in Puerto Rico. P R Health Sci J. 2011; 30(2):51–57. PMID: 21682146.
12. Schinabeck MK, Johnson JL. Osteomyelitis in diabetic foot ulcers: prompt diagnosis can avert amputation. Postgrad Med. 2005; 118(1):11–15. PMID: 16106914.
13. Lipsky BA, Berendt AR, Cornia PB, et al. 2012 Infectious Diseases Society of America clinical practice guideline for the diagnosis and treatment of diabetic foot infections. Clin Infect Dis. 2012; 54(12):e132–e173. PMID: 22619242.
14. Salvana J, Rodner C, Browner BD, Livingston K, Schreiber J, Pesanti E. Chronic osteomyelitis: results obtained by an integrated team approach to management. Conn Med. 2005; 69(4):195–202. PMID: 15926634.
15. Mruk AL, Record KE. Antimicrobial options in the treatment of adult staphylococcal bone and joint infections in an era of drug shortages. Orthopedics. 2012; 35(5):401–407. PMID: 22588396.
Article
16. Berdajs DA, Trampuz A, Ferrari E, Ruchat P, Hurni M, von Segesser LK. Delayed primary versus late secondary wound closure in the treatment of postsurgical sternum osteomyelitis. Interact Cardiovasc Thorac Surg. 2011; 12(6):914–918. PMID: 21372144.
Article
17. Lipsky BA. Osteomyelitis of the foot in diabetic patients. Clin Infect Dis. 1997; 25(6):1318–1326. PMID: 9431370.
Article
18. European Committee on Antimicrobial Susceptibility Testing (EUCAST). Breakpoint tables for interpretation of MICs and zone diameters [Internet]. EUCAST;2011. cited 2014 Jan 5. Available from: http://www.eucast.org/fileadmin/src/media/PDFs/EUCAST_files/Disk_test_documents/EUCAST_breakpoints_v1.3_pdf.pdf.
19. Sheehy SH, Atkins BA, Bejon P, et al. The microbiology of chronic osteomyelitis: prevalence of resistance to common empirical anti-microbial regimens. J Infect. 2010; 60(5):338–343. PMID: 20230854.
Article
20. Trampuz A, Zimmerli W. Diagnosis and treatment of infections associated with fracture-fixation devices. Injury. 2006; 37(Suppl 2):S59–S66. PMID: 16651073.
Article
21. Cunningham R, Cockayne A, Humphreys H. Clinical and molecular aspects of the pathogenesis of Staphylococcus aureus bone and joint infections. J Med Microbiol. 1996; 44(3):157–164. PMID: 8636931.
Article
22. Dubey L, Krasinski K, Hernanz-Schulman M. Osteomyelitis secondary to trauma or infected contiguous soft tissue. Pediatr Infect Dis J. 1988; 7(1):26–34. PMID: 2893333.
Article
23. Ertugrul BM, Oncul O, Tulek N, et al. A prospective, multi-center study: factors related to the management of diabetic foot infections. Eur J Clin Microbiol Infect Dis. 2012; 31(9):2345–2352. PMID: 22354524.
Article
24. Tan JS, Friedman NM, Hazelton-Miller C, Flanagan JP, File TM Jr. Can aggressive treatment of diabetic foot infections reduce the need for above-ankle amputation? Clin Infect Dis. 1996; 23(2):286–291. PMID: 8842265.
Article
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