J Korean Med Sci.  2000 Aug;15(4):413-419. 10.3346/jkms.2000.15.4.413.

Chronological effects of atherogenic diets on the aorta, liver and spleen of rabbits

• Song SH
• Min BI
• Lee JH
• Cho KS

• KMID: 1730637
• DOI: http://doi.org/10.3346/jkms.2000.15.4.413

Abstract

To investigate the temporal progression of atherogenesis on the aorta and involvement of the monocyte-macrophage system in the liver and spleen, we fed 74 rabbits with high fat (14 or 7 gm+ACU-) and cholesterol (2 and 1+ACU-) diets for 4 to over 24 weeks. Using both light and electron microscopies, we found that the bro-fatty areas on the luminal surface of aortas was spread over along the eding time dependently. The fat deposits also in the liver and spleen worsened pending on the time of feeding the atherogenic diets. Not only nocyte-derived foam cells, but also parenchymatous cells in the liver and leen involved become fat-laden cells. According to these results, we propose at there are three stages: 1) the primary seeding, 2) the intermediate turing and 3) the advanced periods. These periods may play very important les in designing the management and treatment of atherosclerotic patients.

Keyword

Dietary Fats; Cholesterol, Dietary; Diet,Atherogenic; Macrophage; Foam Cells; Hepato-Splenic Involvement; Thee Stages of Atherosclerotic Development

MeSH Terms

Animal
Aorta/pathology
Aorta/drug effects+ACo-
Aortic Diseases/pathology+ACo-
Aortic Diseases/etiology
Arteriosclerosis/pathology+ACo-
Arteriosclerosis/etiology
Cholesterol, Dietary/toxicity
Diet, Atherogenic+ACo-
Dietary Fats/toxicity+ACo-
Dose-Response Relationship, Drug
Fatty Liver/pathology+ACo-
Fatty Liver/etiology
Female
Liver/pathology
Liver/drug effects+ACo-
Male
Microscopy, Electron
Rabbits
Spleen/pathology
Spleen/drug effects+ACo-
Splenic Diseases/pathology+ACo-
Splenic Diseases/etiology
Time Factors