Yonsei Med J.  1990 Dec;31(4):359-366. 10.3349/ymj.1990.31.4.359.

An experimental study on prevention of postlaminectomy scar formation

• Lee HM
• Yang KH
• Han DY
• Kim NH

• KMID: 1729583
• DOI: http://doi.org/10.3349/ymj.1990.31.4.359

Abstract

In repeat lumbar surgery for failed back syndrome, well organized fibrous scar tissue is often noted, binding together the dura, nerve roots, and paraspinal muscles. An animal experimental study was done to investigate the prevention of scar formation after lumbar laminectomy by using dacron and sodium hyaluronate. The experimental animals consisted of three groups: 1) control group, 2) D group (covering the laminectomy defect with dacron sheet), and 3) H group (covering the laminectomy defect with sodium hyaluronate gel). Animals were sacrificed at varying intervals (3-12 weeks) and the lumbar spines were evaluated with histologic preparations. Scar adhesion to the dura was most significantly suppressed in the D group, followed by the H group and the control group.

Keyword

Cicatrix; laminectomy; prevention; dacron; sodium hyaluronate

MeSH Terms

Animal
Cicatrix/etiology/*prevention & control
Connective Tissue/pathology
Disease Models, Animal
Dura Mater/pathology
Hyaluronic Acid
*Laminectomy
Polyethylene Terephthalates
Postoperative Complications
Rabbits
Support, Non-U.S. Gov't
Surgical Mesh