Yonsei Med J.  2013 May;54(3):752-762. 10.3349/ymj.2013.54.3.752.

Fresh Frozen Plasma in Pump Priming for Congenital Heart Surgery: Evaluation of Effects on Postoperative Coagulation Profiles Using a Fibrinogen Assay and Rotational Thromboelastometry

• Lee JW
• Yoo YC
• Park HK
• Bang SO
• Lee KY
• Bai SJ

• KMID: 1727894
• DOI: http://doi.org/10.3349/ymj.2013.54.3.752

Abstract

PURPOSE
In this prospective study, the effects of fresh frozen plasma (FFP) included in pump priming for congenital heart surgery in infants and children on post-bypass coagulation profiles were evaluated.
MATERIALS AND METHODS
Either 20% albumin (50-100 mL) or FFP (1-2 units) was added to pump priming for patients randomly allocated into control or treatment groups, respectively. Hematologic assays, including functional fibrinogen level, and rotational thromboelastometry (ROTEM(R)) were measured before skin incision (baseline), after weaning from cardiopulmonary bypass (CPB) and heparin reversal, and at 24 hours (h) in the intensive care unit (ICU).
RESULTS
All the baseline measurements were comparable between the control and treatment groups of infants and children. After heparin reversal, however, significantly higher fibrinogen levels and less reduced ROTEM parameters, which reflect clot formation and firmness, were demonstrated in the treatment groups of infants and children. At 24 h in the ICU, hematologic assays and ROTEM measurements were comparable between the control and treatment groups of infants and children. Transfusion requirements, excluding FFP in pump prime, and postoperative bleeding were comparable between the control and treatment groups of infants and children.
CONCLUSION
Although clinical benefits were not clearly found, the inclusion of FFP in pump priming for congenital heart surgery in infants and children was shown to improve the hemodilution-related hemostatic dysfunction immediately after weaning from CPB and heparin reversal.

Keyword

Congenital heart disease; cardiopulmonary bypass; blood coagulation disorder; fresh frozen plasma

MeSH Terms

Adolescent
*Blood Coagulation
Cardiac Surgical Procedures
Cardiopulmonary Bypass/methods
Child
Child, Preschool
Female
Fibrinogen/*metabolism
Heart Defects, Congenital/*surgery
Humans
Infant
Male
*Plasma
Postoperative Period
Thrombelastography/methods
Fibrinogen

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