Yonsei Med J.  2004 Jun;45(Suppl):S74A6-S74A6. 10.3349/ymj.2004.45.Suppl.74A6.

Clinical Results of Transplantation of Tissue-Engineered Cartilage and Future Direction of Cartilage Repair: Novel Approach with Minimally Invasive Procedure

• Ochi M

• KMID: 1726155
• DOI: http://doi.org/10.3349/ymj.2004.45.Suppl.74A6

Abstract

Articular cartilage has very limited potential to spontaneously heal, because it lacks vessels and is isolated from systemic regulation. No treatment has repaired the defects with long-lasting hyaline cartilage. Recently, a regenerative medicine by a tissue-engineering technique for cartilage repair has been given much attention in the orthopaedic field. In 1994, Brittberg et al. introduced a new technology in which chondrocytes expanded in monolayer culture were transplanted into the cartilage defect of the knee. As a second generation of chondrocyte transplantation, we have been performing transplantation of tissue-engineered cartilage made ex vivo for the treatment of osteochondral defects of the joints since 1996. This signifies a concept shift from cell transplantation to tissue transplantation made ex vivo using tissue-engineering technique. We have reported good clinical results with this surgical treatment. However, extensive basic research is vital to achieve better clinical results with this tissue-engineering technique. I would like to describe our recent research using a minimally invasive tissue-engineering technique to promote cartilage regeneration.

Keyword

Cartilage; tissue-engineering; scaffold