Korean J Pathol.
1999 May;33(5):371-375.
Undescended Testis in the Complete Testicular Feminization Syndrome A report of three cases
- Affiliations
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- 1Department of Pathology, College of Medicine, Keimyung University, Taegu 700-712, Korea.
- 2Department of Obstetrics and Gynecology, College of Medicine, Keimyung University, Taegu 700-712, Korea.
Abstract
- The testicular feminization is the most common type of male pseudohermaphroditism. Mutation of androgen receptor gene impairs normal sexual differentiation in genetic male (46, XY) and subsequently develops secondary female characteristics. We report three cases of complete testicular feminization syndrome with normal development of female external genitalia, but with blindly ended vagina and inguinal or pelvic masses. Microscopic examination of the testes and their adnexa had three components: 1) A testis composed of immature tubules, prominent Leydig cells and a spindle cell stroma resembling ovarian stroma with hamartomatous nodule or Sertoli cell adenoma, 2) a white, whorled, firm, smooth muscle body in the medial pole of the testis, and 3) a lateral adnexal cysts of varying sizes.
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