Korean J Parasitol.
2005 Sep;43(3):123-126. 10.3347/kjp.2005.43.3.123.
Antimalarial activity of thiophenyl- and benzenesulfonyl-dihydroartemisinin
- Affiliations
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- 1Department of Basic Science, Kwandong University College of Medicine, Gangneung 210-701, Korea. sjlee@kd.ac.kr
- 2Department of Chemistry, Yonsei University, Wonju 220-710, Korea.
- 3Department of Parasitology, Kwandong University College of Medicine, Gangneung 210-701, Korea.
- 4Department of Medical Zoology, National Institute of Health, Seoul 122-201, Korea.
- 5Department of Parasitology, Hanyang University College of Medicine, Seoul 133-791, Korea.
- KMID: 1720504
- DOI: http://doi.org/10.3347/kjp.2005.43.3.123
Abstract
- Each diastereomer of 10-thiophenyl- and 10-benzenesulfonyl-dihydroartemisinin was synthesized from artemisinin in three steps, and screened against chloroquine-resistance and chloroquine-sensitive Plasmodium falciparum. Three of the four tested compounds were found to be effective. Especially, 10 beta-benzenesulfonyl-dihydroartemisinin showed stronger antimalarial activity than artemisinin.
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