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Antimalarial activity of thiophenyl- and benzenesulfonyl-dihydroartemisinin

Lee SJ, Oh ST, Park GM, Kim TS, Ryu JS, Choi HK

Each diastereomer of 10-thiophenyl- and 10-benzenesulfonyl-dihydroartemisinin was synthesized from artemisinin in three steps, and screened against chloroquine-resistance and chloroquine-sensitive Plasmodium falciparum. Three of the four tested compounds were found to...
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Prevalence of Drug Resistance-Associated Gene Mutations in Plasmodium vivax in Central China

Lu F, Wang B, Cao J, Sattabongkot J, Zhou H, Zhu G, Kim K, Gao Q, Han ET

  • KMID: 1792136
  • Korean J Parasitol.
  • 2012 Dec;50(4):379-384.
Resistance of Plasmodium spp. to anti-malarial drugs is the primary obstacle in the fight against malaria, and molecular markers for the drug resistance have been applied as an adjunct in...
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Drug Resistance and in Vitro Susceptibility of Plasmodium falciparum in Thailand during 1988-2003

Suwandittakul N, Chaijaroenkul W, Harnyuttanakorn P, Mungthin M, Na Bangchang K

The aim of the present study was to investigate antimalarial drug pressure resulting from the clinical use of different antimalarials in Thailand. The phenotypic diversity of the susceptibility profiles of...
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