Yonsei Med J.  2006 Feb;47(1):63-69. 10.3349/ymj.2006.47.1.63.

Comparison of Efficacy of Cefoperazone/Sulbactam and Imipenem/Cilastatin for Treatment of Acinetobacter Bacteremia

Affiliations
  • 1Department of Internal Medicine and AIDS Research Institute, Yonsei University College of Medicine, 134 Shinchon-dong, Seodaemun-gu, Seoul, Korea. jmkim@yumc.yonsei.ac.kr
  • 2Department of Laboratory Medicine and Research Institute of Bacterial Resistance, Yonsei University College of Medicine, Seoul, Korea.

Abstract

Multiple antibiotic reisistance threatens successful treatment of Acinetobacter baumannii infections worldwide. Increasing interest in the well-known activity of sulbactam against the genus Acinetobacter has been aroused. The purpose of this study was to compare the outcomes for patients with Acinetobacter bacteremia treated with cefoperazone/sulbactam versus imipenem/cilastatin. Forty-seven patients with Acinetobacter baumannii bacteremia were analyzed through a retrospective review of their medical records for antibiotic therapy and clinical outcome. Thirty-five patients were treated with cefoperazone/sulbactam, and twelve patients with imipenem/ cilastatin. The percentage of favorable response after 72 hours was not statistically different between cefoperazone/ sulbactam group and imipenem/ cilastatin group. The mortality rate was not statistically different, too. Cefoperazone/sulbactam was found to be as useful as imipenem/cilastatin for treating patients with Acinetobacter bacteremia.

Keyword

Acinetobacter; bacteremia; cefoperazone/sulbactam; imipenem/cilastatin

MeSH Terms

Sulbactam/*therapeutic use
Protease Inhibitors/therapeutic use
Middle Aged
Male
Imipenem/therapeutic use
Humans
Female
Drug Therapy, Combination
Drug Resistance, Bacterial
Cilastatin/therapeutic use
Cefoperazone/*therapeutic use
Bacteremia/*drug therapy
Anti-Bacterial Agents/*therapeutic use
Aged
Adult
Adolescent
Acinetobacter Infections/*drug therapy/mortality
Acinetobacter/drug effects/isolation & purification
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