Korean J Med.  2009 Apr;76(Suppl 1):S238-S242.

A case of cefotiam-contact anaphylaxis

• Lee KH
• Choi IS
• Lee WJ
• Kang SJ
• Jeong HK

Abstract

Anaphylaxis caused by beta-lactam antibiotics usually develops following the systemic administration of the drug, although it can also occur with trivial contact of the drug on the skin in extraordinarily sensitive individuals. Cefotiam is a second-generation cephalosporin developed in Japan, and cefotiam-induced contact urticaria and systemic symptoms (contact urticaria syndrome) have been reported in several nurses from Japan and Korea. Considering the serious nature of the systemic manifestations, such as hypotension, contact anaphylaxis is a more appropriate name for severe forms of the disease than contact urticaria syndrome. No previous study has reported a case involving contact urticaria syndrome to multiple drugs. We describe a case of cefotiam-induced contact anaphylactic shock combined with cefoperazone/sulbactam-induced contact urticaria syndrome in a 24-year-old nurse. She exhibited positive skin prick test responses to both cefotiam and cefoperazone/sulbactam.

Keyword

Anaphylaxis; Cefoperazone; Cefotiam; Contact urticaria syndrome; Sulbactam

MeSH Terms

Anaphylaxis
Anti-Bacterial Agents
Cefoperazone
Cefotiam
Humans
Hypotension
Japan
Korea
Skin
Sulbactam
Urticaria
Young Adult
Anti-Bacterial Agents
Cefoperazone
Cefotiam
Sulbactam