Korean J Parasitol.
2013 Jun;51(3):289-295. 10.3347/kjp.2013.51.3.289.
Age-Related CD4+CD25+Foxp3+ Regulatory T-Cell Responses During Plasmodium berghei ANKA Infection in Mice Susceptible or Resistant to Cerebral Malaria
- Affiliations
-
- 1Department of Immunology, College of Basic Medical Sciences, China Medical University, Shenyang 110001, China. ymcao@mail.cmu.edu.cn
- 2Department of Immunology, College of Basic Medical Sciences, Liaoning Medical University, Jinzhou 121000, China.
- 3Department of Laboratory Medicine, the First Hospital of China Medical University, Shenyang 110001, China.
- 4The Key Laboratory of AIDS Immunology of Ministry of Health, the First Hospital of China Medical University, Shenyang 110001, China.
- KMID: 1715702
- DOI: http://doi.org/10.3347/kjp.2013.51.3.289
Abstract
- Different functions have been attributed to CD4+CD25+Foxp3+ regulatory T-cells (Tregs) during malaria infection. Herein, we describe the disparity in Treg response and pro- and anti-inflammatory cytokines during infection with Plasmodium berghei ANKA between young (3-week-old) and middle-aged (8-month-old) C57BL/6 mice. Young mice were susceptible to cerebral malaria (CM), while the middle-aged mice were resistant to CM and succumbed to hyperparasitemia and severe anemia. The levels of pro-inflammatory cytokines, such as TNF-alpha, in young CM-susceptible mice were markedly higher than in middle-aged CM-resistant mice. An increased absolute number of Tregs 3-5 days post-inoculation, co-occurring with elevated IL-10 levels, was observed in middle-aged CM-resistant mice but not in young CM-susceptible mice. Our findings suggest that Treg proliferation might be associated with the suppression of excessive pro-inflammatory Th1 response during early malaria infection, leading to resistance to CM in the middle-aged mice, possibly in an IL-10-dependent manner.
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Previous Infection with Plasmodium berghei Confers Resistance to Toxoplasma gondii Infection in Mice
- Peripheral Generation of CD4+ CD25+ Foxp3+ Regulatory T Cells
- A Study on the Number of Circulating CD4+CD25+Foxp3+ Regulatory T Cells and CD4+CD25-Foxp3+ T Cells in Psoriasis
- Characterization of Plasmodium berghei Homologues of T-cell Immunomodulatory Protein as a New Potential Candidate for Protecting against Experimental Cerebral Malaria
- Dynamic Frequency of Blood CD4+CD25+ Regulatory T Cells in Rats with Collagen-induced Arthritis
