Korean J Parasitol.
2011 Mar;49(1):73-77. 10.3347/kjp.2011.49.1.73.
A Paragonimiasis Patient with Allergic Reaction to Praziquantel and Resistance to Triclabendazole: Successful Treatment after Desensitization to Praziquantel
- Affiliations
-
- 1Department of Medicine, Gachon University Gil Medical Center, Incheon 405-760, Korea. allergy21@hotmail.com
- 2Department of Thoracic Surgery, Gachon University Gil Medical Center, Incheon 405-760, Korea.
- 3Department of Radiology, Gachon University Gil Medical Center, Incheon 405-760, Korea.
- KMID: 1715637
- DOI: http://doi.org/10.3347/kjp.2011.49.1.73
Abstract
- Paragonimiasis is an infectious disease caused by trematodes of the genus Paragonimus. This trematode can be treated successfully with praziquantel in more than 90% of the cases. Although praziquantel is generally well tolerated, anaphylactic reactions to this drug have been reported in a few cases. We report here a 46-year-old Korean female with paragonimiasis, presumed to be due to Paragonimus westermani, who displayed an allergic reaction to praziquantel and resistance to triclabendazole treatment. The patient was successfully treated with praziquantel following a rapid desensitization procedure. Desensitization to praziquantel could be considered when no alternative drugs are available.
MeSH Terms
-
Animals
Benzimidazoles/*therapeutic use
*Desensitization, Immunologic
Drug Hypersensitivity/etiology/immunology/*therapy
*Drug Resistance
Female
Humans
Middle Aged
Paragonimiasis/*drug therapy/immunology/parasitology
Paragonimus/isolation & purification/physiology
Praziquantel/*adverse effects/*immunology/therapeutic use
Treatment Outcome
