Korean J Parasitol.  1999 Jun;37(2):77-83. 10.3347/kjp.1999.37.2.77.

Long-lasting sonographic and histopathological findings in cured clonorchiasis of rabbits

• Choi D
• Lim JH
• Kim SK
• Kim EY
• Lee M
• Hong ST

• KMID: 1715269
• DOI: http://doi.org/10.3347/kjp.1999.37.2.77

Abstract

To ascertain residual sonographic and histopathological findings of clonorchiasis after treatment, the present study evaluated sonographic findings in rabbits which were infected with 500 metacercariae of C. sinensis every 6 months for 18 months after treatment with praziquantel. The sonographic findings were analyzed in terms of intrahepatic bile duct dilatation and periductal echogenicity, and histopathological findings were observed after the last sonographic examination. Compared with the sonographic findings before treatment, dilatation of the intrahepatic bile ducts became mild to some degree in four of the seven cases and increased periductal echogenicity resolved in four of them. The histopathological specimens after 18 months showed that periductal inflammation has almost resolved but moderate dilatation of the intrahepatic ducts and mucosal hyperplasia persisted. The periductal fibrosis minimally resolved. The long-lasting sonographic findings in cured clonorchiasis make sonography less specific.

MeSH Terms

Animal
Antiplatyhelmintic Agents/therapeutic use
Bile Ducts, Intrahepatic/ultrasonography
Bile Ducts, Intrahepatic/pathology
Clonorchiasis/ultrasonography*
Clonorchiasis/pathology*
Clonorchiasis/drug therapy
Dilatation, Pathologic
Intestinal Diseases, Parasitic/ultrasonography*
Intestinal Diseases, Parasitic/pathology*
Intestinal Diseases, Parasitic/drug therapy
Praziquantel/therapeutic use
Rabbits
Ultrasonography, Interventional