J Korean Med Sci.  2007 Oct;22(5):908-911. 10.3346/jkms.2007.22.5.908.

Acute Marchiafava-Bignami Disease with Widespread Callosal and Cortical Lesions

• Kim MJ
• Kim JK
• Yoo BG
• Kim KS
• Jo YD

• KMID: 1713302
• DOI: http://doi.org/10.3346/jkms.2007.22.5.908

Abstract

Marchiafava-Bignami disease (MBD) is a rare alcohol-related disorder that results in progressive demyelination and necrosis of the corpus callosum. The process may extend to the optic chiasm and tracts, cerebellar peduncle, subcortical resion, neighboring white matter, and rarely, cortical gray matter. We report a case of MBD in which fluid-attenuated inversion recovery and diffusion magnetic resonance imaging studies revealed symmetrical hyperintense lesions in the cerebral cortex in addition to the callosal lesions.

Keyword

Alcohol-Related Disorders; Cerebral Cortex; Diffusion Magnetic Resonance Imaging

MeSH Terms

Alcoholism/complications
Brain/pathology
Cerebral Cortex/*pathology
Corpus Callosum/*pathology
Demyelinating Diseases/pathology
Diffusion Magnetic Resonance Imaging/methods
Humans
Male
Marchiafava-Bignami Disease/*diagnosis/*pathology/*therapy
Middle Aged
Necrosis/pathology
Neurodegenerative Diseases/pathology
Optic Chiasm/pathology
Seizures
Time Factors
Treatment Outcome
Vitamin B Complex/therapeutic use

Figure

• 

  Fig. 1 Diffusion weighted images (A, B) and T2-weighted image (C) show bright, high signal intensities in the corpus callosum and bilateral frontal cortex.

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  Fig. 2 Follow-up Fluid attenuated inversion recovery and T2-weighted images after months show decreased high signal intensities of bilateral frontal cortex and corpus callosum (A, B). Sagittal T1-weighted image reveals atrophy of the corpus callosum with multiple focal areas of presumed necrosis in the genu, body, and splenium (C).

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