Clin Mol Hepatol.  2013 Sep;19(3):305-308. 10.3350/cmh.2013.19.3.305.

Co-development of autoimmune hepatitis and Sjogren's syndrome triggered by the administration of herbal medicines

• Oh HJ
• Mok YM
• Baek MS
• Lee JK
• Seo BS
• Kim TH
• Choi KH
• Hwang IK
• Ra JE
• Oh YR
• Kim YS
• Cho EY
• Kim HC
• Sohn YW

• KMID: 1705209
• DOI: http://doi.org/10.3350/cmh.2013.19.3.305

Abstract

Autoimmune hepatitis (AIH) has been reported in association with Sjogren's syndrome (SS). Drug-induced AIH has been rarely reported. A rare case of the co-development of AIH and SS in a 53-year-old woman after the consumption of herbal medicines is described. After admission, the patient complained of dryness in her mouth, and she was subsequently diagnosed with SS, which had not been detected previously. The patient's bilirubin and aminotransferase levels initially decreased following conservative management; however, they later began to progressively increase. A diagnosis of AIH was made based on the scoring system proposed by the International Autoimmune Hepatitis Group. The patient was administered a combination of prednisolone and azathioprine, and the results of follow-up liver-function tests were found to be within the normal range. This is an unusual case of AIH and SS triggered simultaneously by the administration of herbal medicines.

Keyword

Autoimmune hepatitis; Sjogren's syndrome; Herbal medicine

MeSH Terms

Alanine Transaminase/blood
Aspartate Aminotransferases/blood
Azathioprine/therapeutic use
Bilirubin/blood
Female
Hepatitis, Autoimmune/complications/*diagnosis/drug therapy
*Herbal Medicine
Humans
Liver/pathology
Liver Function Tests
Middle Aged
Prednisolone/therapeutic use
Sjogren's Syndrome/complications/*diagnosis/drug therapy
Alanine Transaminase
Aspartate Aminotransferases
Azathioprine
Bilirubin
Prednisolone