J Korean Pediatr Soc.  1993 Apr;36(4):589-595.

Recurrent rhinocerebral mucormycosis: A case report

Abstract

A case of recurrent rhinocerebral mucormycosis that has occurred during an induction chemotherapy for acute megakaryocytic leukemia in a 10 year-old boy is reported. He had suffered from high fever, proptosis, right eye ball pain and necrotic inflammation of hard palate during the chemotherapy of leukemia. CT scan of the paranasal sinus showed inflammatory change of right ethmoid and maxillary sinuses, and right orbital cystic mass which displaced medial rectus muscle. Pathologic examination of the inflammatory mass revealed mucormycosis with characteristic hyphae invading vessel walls. He was managed with 2 times of extensive debridement of necrotic tissue and currettage of cystic mass, and intravenous amphotericin-B for 80 days with apparent improvement. Seven months after discharge from the hospital, necrosis of posterior nasal septum and hard palate was noted for second time. It was managed again with 2 times of extensive debridement. Since this last operation he is on follow-up for 16 months uneventfully and is on therapy with low dose Ara-C in continuous remission.

Keyword

Rhinocerebral mucormycosis; Recurrent; Acute megakaryocytic leukemia

MeSH Terms

Child
Cytarabine
Debridement
Drug Therapy
Exophthalmos
Fever
Follow-Up Studies
Humans
Hyphae
Induction Chemotherapy
Inflammation
Leukemia
Leukemia, Megakaryoblastic, Acute
Male
Maxillary Sinus
Mucormycosis*
Nasal Septum
Necrosis
Orbit
Palate, Hard
Tomography, X-Ray Computed
Cytarabine
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