Korean J Dermatol.  1987 Apr;25(2):169-175.

A Study on the T Lymphocyte Subsets and Serum IgE in Patients with Atopic Dermatitis

• Kang SJ
• Kim SH
• Lee YS

Abstract

This study was undertaken to elucidate any quantitative abnormalities of Tlymphocyte subsets (helper/inducer T cell; T cell and suppressor/cytotoxic T cell: T cell) and IgE levels in the peripheraI blood in atopic dermatitis patients by using monoclonal antibodies and enzyme immunoassay, respectively. In addition we have tried to ascertain whether there are any correlations betveen such immuiiologic abnormalities and the severity of the disease. The results showed that there were significant decrease in the mean percentage of T Cells and increase in the mean value of T/T cell ratios in patients with atopic dermatitis. These changes seem to relate to the severity of the disease when evaluated as groups. A significant increase in the mean value of serum IgE was found in atopic dermatitis patients and the change was related to the severity of the disease. But increase of serum IgE level did not correlated closely with the T cell abnormalities in each patients.

Keyword

Atopic dermatitis; T cell subsets; IgE; Monoclonal antibodies169

MeSH Terms

Antibodies, Monoclonal
Dermatitis, Atopic*
Humans
Immunoenzyme Techniques
Immunoglobulin E*
T-Lymphocyte Subsets*
T-Lymphocytes
Antibodies, Monoclonal
Immunoglobulin E