Korean J Dermatol.  1985 Dec;23(6):726-735.

Study on the Effects of Epidermal Growth Factor on Epidermal and Hair Growth in the Mouse

• Lee YS
• Choi JH

Abstract

Epiclerrnal growth factor(EGF), a low-molecular-weight polypeptide chain consisting of 53 amino acids, stimulates the growth and keratinization of epidermal cells. Recently, some authors reported that hair growth rate and follicular bulb growth were inhibited by EGF in neonatal mice. Since the hair and follicular cells are of epidermal origin, the effect of EGF would appear to be inconsistent with its role promoting the proliferation and differentiation of epidermal cells in vivo and in vitro. We have investigated the effects of EGF on the hair and epidermis in adult male mouse. The results are summarized as follows: l. 1'he hair length and maximum diameter were significantly reduced in EGF- treated regions compared with control group, and inhibition of hair growth was correlated with EGF dose. Thickness of the epidermis was significantly increased in EGF-treated regions compared with control group, and proliferation of the epidermis was correlated with EGF dose. 3 There were no significant differences in the hair length, maximum diameter, and egidermal thickness between untreated contralateral right mid-side regions of EGF-treated groups and control group.

Keyword

Epidermal growth factor ( EGF ); Epidermal growth; Hair growth726

MeSH Terms

Adult
Amino Acids
Animals
Epidermal Growth Factor*
Epidermis
Hair*
Humans
Male
Mice*
Amino Acids
Epidermal Growth Factor