Korean J Dermatol.  1982 Jun;20(3):431-436.

Two Cases of Sex-linked Ichthyosis Improved by an Oral Aromatic Retinoid (Ro 10 - 9359)

• Jang JE
• Kook HI

Abstract

We present the therapeutic effects of an aromatic retinoid (Ro 10-9359) in two cases of sex-linked ichthyosis. Case 1, Uncle of Case 2, was a 24-year-old male who had had dark brown scales on the trunk and upper extremities for 15 years. Case 2 was a 10-year-old boy who had had dirty brown scales on the trunk and lower extremities since 3 years of age. The diagnosis of sex-linked ichthyosis was made by characteristic scales and histopathologic findings. Initially, both patients received an oral aromatic retinoid (Ro 10-9359) with a daily dose of 1.5mg/kg body weight for the first two weeks. Thereafter the drug was tapered gradually to the dose of 0.5mg/kg body weight according to the therapeutic response. There was near complete clearing of the skin lesions in both patients after 10 weeks treatment. Side effects were of mild intensity and included dryness of mouth and nose, chelitis, paronychia and arthralgia of knee joint.

MeSH Terms

Arthralgia
Body Weight
Child
Diagnosis
Humans
Ichthyosis*
Knee Joint
Lower Extremity
Male
Mouth
Nose
Paronychia
Skin
Upper Extremity
Weights and Measures
Young Adult