Korean J Dermatol.
1981 Jun;19(3):271-277.
A Study on the Effect of Antihistamine in Patch Test Reaction
Abstract
- The patch test reaction is artificially induced allergic contact dermatitis to prove the cause of allergic contact dermatitis. Allergic contact dermatitis is classically regarded as a delayed hypersensitivity composed of the simple cutanous infiltration of lymphocytes and macrophages. Recently several authors observed new morphologic findings in allergic contact dermatitis including infiltration and piecemeal degranulation of basophils, degranulation and replication of fixed tissue mast, cells, increased vascular permeability leading to dermal and epidermal edema, microvascular alterations affecting endothelial cells and pericytes, and activation of the clotting system, with deposition of fibrin in a characeristic inravascular pattern in the reticular dermis. And they proposed new hypotbesis that the vaoactive amines released by basophils and mast cells have the crucial role in eliciting allergic contact dermatitis. We studied the effect of antihistamine on allergic contact dermatitis caused by dinitrochlorobenzene(DNCB). with phenirarnine maleate,(Avil) 136.5mg/d in 15 young adult male persons. Clinically the degree of the skin reaction is decreased in 9 of 15 persons after tie ingestion of pheniramine maleate. and histopathologically the epidermal and dermal changes are ameliorated in accordance with the clinic':1 improvement. Our results indicate that the histamine also participates in the pathogenesis of allergic contact dermatitis.
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