Korean J Dermatol.  1980 Dec;18(6):579-584.

A Case of Histiocytic Medullary Reticulosis with Cutaneous Lesions

• Jeon KJ
• Yoo DW
• Kim YW
• Lee DW

Abstract

Histiocytic medullary reticulosis is a rare, uniformly fatal, acute disease of the reticuloendothelial system. The disease is associated with fever, malaise, weakness, weight loss, lymphadenopathy, hepatosplenomegaly, jaundice, and purpura. Common laboratory findings are severe anemia, leukopenia, and thrombocytopenia. A 49-year-old male patient is described who had multiple purple nodules and tumors in the skin. A biopsy taken from a skin lesion showed a diffuse proliferation of atypical histiocytes in the dermis and subcutaneous tissue.However, erythrophagocytosis of these atypical histiocytes was not seen.

MeSH Terms

Acute Disease
Anemia
Biopsy
Dermis
Fever
Histiocytes
Humans
Jaundice
Leukopenia
Lymphatic Diseases
Male
Middle Aged
Mononuclear Phagocyte System
Purpura
Skin
Thrombocytopenia
Weight Loss