Korean J Dermatol.
1980 Feb;18(1):39-42.
Studies on the Effects fo Topically Applied Ginseng Saponin on Human Skin: III. Evaluation of anti-inflammatory effect
Abstract
- The therapeutic properties of Ginseng have been known as popular Chinese midecine since time immemorial. It has been used in Korea, China, Tibet, Indonesia and India for thousands of years under various presentations, such as tes, tinctures, wines, pills, and unguents for the prevention of aging, tireness, headaches, amnesia, tuberculosis, diabetes, illness of the liver, heart, kidneys, nervous system etc. The main effective component of Ginseng has recently been considered to be saponins according to the chemical studies by Shibata's group and the pharmacological studies by Takagi et al., and also through the studies of Brekhman. The purpose of this study is to evaluate the response of topically applied Ginseng total saponin against inflammation. To induce the inflammation of skin the backs of 20 volunteers were treated with 10% sodium lauryl sulfate solution under occlusion for one hour. After removal of sodium lauryl sulfate. Gineseng total saponin ointment in various concentrations(2.5, 5, 10%) is topically applied under occlusion for 48 hours. Erythema on the areas treated with Ginseng total saponin ointment was significantly reduced than the control area. It is suggested that Ginseng total saponin has an anti-inflammatory effect on the inflammation of skin induced by sodium lauryl sulfate.
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