J Korean Ophthalmol Soc.  1980 Sep;21(3):215-218.

Electron Microscopic Investigation of Finer Structurtes of Rabbit Retina on the Experimental Toxic Lesion

• Kim JC

Abstract

Electron microscopic observation was carried out on the alterations of finer structures of retina following the daily intraperitoneal injections of BRC (benzenhexachloride) and combination of BRC with copper for 4 weeks and 6 weeks to the rabbit respectively. 1. In both groups, vesicle formation due to sporadic disintegration and elimination of axons in the nerve fiber layer appeared. 2. Formation of large vesicles was noticeable in the cytoplasm of retinal pigment epithelial cells in both 4 weeks and 6 weeks groups which was considered to be a relative enlargement of smooth surfaced endoplasmic reticulum (SER) by the increased enzymatic activities in response to the toxins. Focal thickening of Bruch's membrane in the group of 4 weeks and focal destruction of the Bruch's membrane in the group of 6 Weeks were observed. 3. Between the BRC inoculated group and ERC combined with copper inoculated group, no conspicuous difference in findings was recognized. More severe alterations of finer retinal structures in the 6 weeks group than in the 4 weeks group were demonstrated.

MeSH Terms

Axons
Bruch Membrane
Copper
Cytoplasm
Endoplasmic Reticulum
Epithelial Cells
Injections, Intraperitoneal
Nerve Fibers
Retina*
Retinaldehyde
Copper
Retinaldehyde