Korean J Dermatol.  1977 Dec;15(4):483-492.

Scleroderma Treated with Penicillamine-D

• Choi YC
• Park YK
• Lee SN

Abstract

Scleroderma is an incidious and chronic disease of unknown cause. The clinical picute of scleroderma is characterized by the apperance of circumscribed of diffuse, hard, smooth, ivory colored areas that are immobile upon upon the underlying tissues. It may be classified to as a localized form (morphea) and a systemic scleroderma or progressive systemic sclerosis (PSS) which is characterized by diffuse involvment of the connective tissue of the skin and certain intemal organs. The authors observed 3 cases of PSS and 6 cases of morphea. They have complained of marked sclerosis or thickening of skin or slowly developing dyspneadue to interstitial pulmonary fibrosis which were confirmed by chest X-ray. Recently, penicillamine-D has been advocated as a beneficial agent in scleroderma by Asboe-Hansen. therefore, penicillamine-D was administered to the above patients. Two of PSS were markedly improved with normal skin softness. Two of morphea were also moderately improved. Other patients remained stationary or no effect.

MeSH Terms

Chronic Disease
Connective Tissue
Humans
Pulmonary Fibrosis
Scleroderma, Diffuse
Scleroderma, Localized
Scleroderma, Systemic
Sclerosis
Skin
Thorax