J Korean Ophthalmol Soc.  1972 Sep;13(3):121-126.

Experimental Degeneration of the Rabbits Retina by Sodium Glutamate

• Lee HS

Abstract

Intravitreal and intraperitoneal administrations of sodium L-glutamate induced the retinal degenerations in adult rabbits. Electroretiongram was completely extinguished by the intravitreal injection of glutamate (50mg in 0.1ml) followed by slight recovery. The retina showed marked thinning with almost diffuse degeneration in all retinal layers. Intraperitoneal injection of a sigle large dose of glutamate(8g/Kg) produced moderate reduction in the amplitudes of a-and b-waves with degenerative changes in the retina, mainly involving the inner layers and the periphery of the fundus, parallel to the ERG changes. Administrations of small doses (2.5g/Kg and 5.0g/Kg) for 7 days induced moderate reduction in the a-and b-waves with slight histological changes, especially marked in the inner layers of the retina. Possible mechanisms of the toxic effects of glutamate were discussed.

MeSH Terms

Adult
Glutamic Acid
Humans
Injections, Intraperitoneal
Intravitreal Injections
Rabbits*
Retina*
Retinal Degeneration
Retinaldehyde
Sodium Glutamate*
Sodium*
Glutamic Acid
Retinaldehyde
Sodium
Sodium Glutamate