1. Huber HL, Koessler KK. The pathology of fatal asthma. Arch Intern Med. 1922. 30:689–760.
2. James AL. Stewart AG, editor. Relationship between airway wall thickness and airway hyperresponsiveness. Airway wall remodeling in asthma. 1997. New York: CRC Press;1–28.
3. Jenkins HA, Cool C, Szefler SJ, Covar R, Brugman S, Gelfand EW, et al. Histopathology of severe childhood asthma: a case series. Chest. 2003. 124:32–41.
4. Payne NR, Rogers AV, Adelroth E, Bandi V, Guntupalli KK, Bush A, et al. Early thickening of the reticular basement membrane in children with difficult asthma. Am J Respir Crit Care Med. 2003. 167:78–82.
5. Moreno RH, Hogg JC, Pare PD. Mechanics of airway narrowing. Am Rev Respir Dis. 1986. 133:1171–1180.
6. James AL, Pare PD, Hogg JC. The mechanics of airway narrowing in asthma. Am Rev Respir Dis. 1989. 139:242–246.
7. Davies DE, Wicks J, Powell RM, Puddicombe SM, Holgate ST. Airway remodeling in asthma: new insights. J Allergy Clin Immunol. 2003. 111:215–225.
8. Knight DA, Lane CL, Stick SM. Does aberrant activation of the epithelialmesenchymal trophic unit play a key role in asthma or is it an unimportant sideshow? Curr Opin Pharmacol. 2004. 4:251–256.
9. Fernandes DJ, Mitchell RW, Lakser O, Dowell M, Stewart AG, Solwy J. Do inflammatory mediators influence the contribution of airway smooth muscle contraction to airway hyperresponsiveness in asthma? J Appl Physiol. 2003. 95:844–853.
10. Beckett PA, Howarth PH. Pharmacotherapy and airway remodelling in asthma? Thorax. 2003. 58:163–174.
11. Ricciardolo FL, di Stefano A, van Krieken JH, Sont JK, van Schadewijk A, Rabe KF, et al. Proliferation and inflammation in bronchial epithelium after allergen in atopic asthmatics. Clin Exp Allergy. 2003. 33:905–911.
12. Dosanjh A, Zuraw B. Endothelin-1 (ET-1) decreases human bronchial epithelial cell migration and proliferation: implications for airway remodeling in asthma. J Asthma. 2003. 40:883–886.
13. Kumar RK, Herbert C, Foster PS. Expression of growth factors by airway epithelial cells in a model of chronic asthma: regulation and relationship to subepithelial fibrosis. Clin Exp Allergy. 2004. 34:567–575.
14. Ebina M, Takahashi T, Chiba T, Motomiya M. Cellular hypertrophy and hyperplasia of airway smooth muscles underlying bronchial asthma: a 3-D morphometric study. Am Rev Respir Dis. 1993. 148:720–726.
15. Woodruff PG, Dolganov GM, Ferrando RE, Donnelly S, Hays SR, Solberg OD, et al. Hyperplasia of smooth muscle in mild to moderate asthma without changes in cell size or gene expression. Am J Respir Crit Care Med. 2004. 169:1001–1006.
16. Benayoun L, Druilhe A, Drombet M, Aubier M, Pretolani M. Airway structural alterations selectively associated with severe asthma. Am J Respir Crit Care Med. 2003. 167:1360–1368.
17. Johnson PR, Roth M, Tamm M, Hughes M, Ge Q, King G, et al. Airway smooth muscle cell proliferation is increased in asthma. Am J Respir Crit Care Med. 2001. 164:474–477.
18. Roth M, Johnson PR, Borger P, Bihl MP, Rudiger JJ, King GG, et al. Dysfunctional interaction of C/EBPalpha and the glucocorticoid receptor in asthmatic bronchial smoothmuscle cells. N Engl J Med. 2004. 351:560–574.
19. Capra V, Habib A, Accomazzo MR, Ravasi S, Citro S, Levy-Toledano S, et al. Thromboxane prostanoid receptor in human airway smooth muscle cells: a relevant role in proliferation. Eur J Pharmacol. 2003. 474:149–159.
20. Zhou L, Li J, Goldsmith AM, Newcomb DC, Giannola DM, Vosk RG, et al. Human bronchial smooth muscle cell lines show a hypertrophic phenotype typical of severe asthma. Am J Respir Crit Care Med. 2004. 169:703–711.
21. Halayko AJ, Kartha S, Stelmack GL, McConville J, Tam J, Camoretti-Mercado B, et al. PI(3)Kinase/TOR/p70S6K regulates contractile protein accumulation in airway myocyte differentiation. Am J Respir Cell Mol Biol. 2004. 31:266–275.
22. Brewster CE, Howarth PH, Djukanovic R, Wilson J, Holgate ST, Roche WR. Myofibroblasts and subepithelial fibrosis in bronchial asthma. Am J Respir Cell Mol Biol. 1990. 3:507–511.
23. Batra V, Musani AI, Hastie AT, Khurana S, Carpenter KA, Zangrilli JG, et al. Bronchoalveolar lavage fluid concentrations of transforming growth factor (TGF)-beta1, TGF-beta2, interleukin (IL)-4 and IL-13 after segmental allergen challenge and their effects on alphasmooth alphasmooth muscle actin and collagen III synthesis by primary human lung fibroblasts. Clin Exp Allergy. 2004. 34:437–444.
24. Bergeron C, Page N, Joubert P, Barbeau B, Hamid Q, Chakir J. Regulation of procollagen I (alpha1) by interleukin-4 in human bronchial fibroblasts: a possible role in airway remodeling in asthma. Clin Exp Allergy. 2003. 33:1389–1397.
25. Schmidt M, Sun G, Stacey MA, Mori L, Mattoli S. Identification of circulating fibrocytes as precursors of bronchial myofibroblasts in asthma. J Immunol. 2003. 171:380–389.
26. Nakamura Y, Esnault S, Maeda T, Kelly EA, Malter JS, Jarjour NN. Ets-1 regulates TNF-alpha-induced matrix metalloproteinase-9 and tenascin expression in primary bronchial fibroblasts. J Immunol. 2004. 172:1945–1952.
27. Shute JK, Solic N, Shimizu J, McConnell W, Redington AE, Howarth PH. Epithelial expression and release of FGF-2 from heparan sulphate binding sites in bronchial tissue in asthma. Thorax. 2004. 59:557–562.
29. Johnson PR, Burgess JK, Underwood PA, Au W, Poniris MH, Tamm M, et al. Extracellular matrix proteins modulate asthmatic airway smooth muscle cell proliferation via an autocrine mechanism. J Allergy Clin Immunol. 2004. 113:690–696.
30. Freyer AM, Billington CK, Penn RB, Hall IP. Extracellular matrix modulates {beta}2-adrenergic receptor signalling in human airway smooth muscle cells. Am J Respir Cell Mol Biol. 2004. 31:440–445.
31. Potter-Perigo S, Baker C, Tsoi C, Braun KR, Isenhath S, Altman GM, et al. Regulation of proteoglycan synthesis by leukotriene d4 and epidermal growth factor in bronchial smooth muscle cells. Am J Respir Cell Mol Biol. 2004. 30:101–108.
32. McParland BE, Macklem PT, Pare PD. Airway wall remodeling: friend or foe? J Appl Physiol. 2003. 95:426–434.
33. Mauad T, Silva LF, Santos MA, Grinberg L, Bernardi FD, Martins MA, et al. Abnormal alveolar attachments with decreased elastic fiber content in distal lung in fatal asthma. Am J Respir Crit Care Med. 2004. 170:857–862.
34. Fredberg JJ, Inouye D, Miller B, Nathan M, Jafari S, Raboudi SH, et al. Airway smooth muscle, tidal stretches, and dynamically determined contractile states. Am J Respir Crit Care Med. 1997. 156:1752–1759.
35. Gelb AF, Licuanan J, Shinar CM, Zamel N. Unsuspected loss of lung elastic recoil in chronic persistent asthma. Chest. 2002. 121:715–721.
36. Mauroy B, Filoche M, Weibel ER, Sapoval B. An optimal bronchial tree may be dangerous. Nature. 2004. 427:633–636.
37. Niimi A, Matsumoto H, Takemura M, Ueda T, Chin K, Mishima M. Relationship of airway wall thickness to airway sensitivity and airway reactivity in asthma. Am J Respir Crit Care Med. 2003. 168:983–988.
38. Pare PD. Airway hyperresponsiveness in asthma: geometry is not everything. Am J Respir Crit Care Med. 2003. 168:913–914.
39. Bumbacea D, Campbell D, Nguyen L, Carr D, Barnes PJ, Robinson D, et al. Parameters associated with persistent airflow obstruction in chronic severe asthma. Eur Respir J. 2004. 24:122–128.
40. Deng L, Fairbank NJ, Fabry B, Smith PG, Maksym GN. Localized mechanical stress induces timeependent actin cytoskeletal remodeling and stiffening in cultured airway smooth muscle cells. Am J Physiol Cell Physiol. 2004. 287:C440–C448.
41. Bonacci JV, Harris T, Stewart AG. Impact of extracellular matrix and strain on proliferation of bovine airway smooth muscle. Clin Exp Pharmacol Physiol. 2003. 30:324–328.
42. Ludwig MS, Ftouhi-Paquin N, Huang W, Page N, Chakir J, Hamid Q. Mechanical strain enhances proteoglycan message in fibroblasts from asthmatic subjects. Clin Exp Allergy. 2004. 34:926–930.
43. An SS, Fabry B, Mellema M, Bursac P, Gerthoffer WT, Kayyali US, et al. Role of heat shock protein 27 in cytoskeletal remodeling of the airway smooth muscle cell. J Appl Physiol. 2004. 96:1701–1713.
44. Blackburn MR, Lee CG, Young HW, Young HW, Zhu Z, Chunn JL, et al. Adenosine mediates IL-13-induced inflammation and remodeling in the lung and interacts in an IL-13-adenosine amplification pathway. J Clin Invest. 2003. 112:332–344.
45. Grunig G. IL-13 and adenosine: partners in a molecular dance? J Clin Invest. 2003. 112:329–331.
46. Flood-Page P, Menzies-Gow A, Phipps S, Ying S, Wangoo A, Ludwig MS, et al. Anti-IL-5 treatment reduces deposition of ECM proteins in the bronchial subepithelial basement membrane of mild atopic asthmatics. J Clin Invest. 2003. 112:1029–1036.
47. Foster PS, Webb DC, Yang M, Herbert C, Kumar RK. Dissociation of T helper type 2 cytokinedependent airway lesions from signal transducer and activator of transcription transcription 6 signalling in experimental chronic asthma. Clin Exp Allergy. 2003. 33:688–695.
48. Chakir J, Shannon J, Molet S, Fukakusa M, Elias J, Laviolette M, et al. Airway remodeling-associated mediators in moderate to severe asthma: effect of steroids on TGF-beta, IL-11, IL-17, and type I and type III collagen expression. J Allergy Clin Immunol. 2003. 111:1293–1298.
49. Johnson JR, Wiley RE, Fattouh R, Swirski FK, Gajewska BU, Coyle AJ, et al. Continuous exposure to house dust mite elicits chronic airway inflammation and structural remodeling. Am J Respir Crit Care Med. 2004. 169:378–385.
50. Laprise C, Sladek R, Ponton A, Bernier MC, Hudson TJ, Laviolette M. Functional classes of bronchial mucosa genes that are differentially expressed in asthma. BMC Genomics. 2004. 5:21.
51. Jongepier H, Boezen HM, Dijkstra A, Howard TD, Vonk JM, Koppelman GH, et al. Polymorphisms of the ADAM33 gene are associated with accelerated lung function decline in asthma. Clin Exp Allergy. 2004. 34:757–760.
52. Mahut B, Delclaux C, Tillie-Leblond I, Gosset P, Delacourt C, Zerah-Lancner F, et al. Both inflammation and remodeling influence nitric oxide output in children with refractory asthma. J Allergy Clin Immunol. 2004. 113:252–256.
53. Cataldo DD, Gueders M, Munaut C, Rocks N, Bartsch P, Foidart JM, et al. Matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases mRNA transcripts in the bronchial secretions of asthmatics. Lab Invest. 2004. 84:418–424.
54. James AL, Maxwell PS, Pearce-Pinto G, Elliot JG, Carroll NG. The relationship of reticular basement membrane thickness to airway wall remodeling in asthma. Am J Respir Crit Care Med. 2002. 166:1590–1595.
55. Shaw TJ, Wakely SL, Peebles CR, Mehta RL, Turner JM, Wilson SJ, et al. Endobronchial ultrasound to assess airway wall thickening: validation in vitro and in vivo. Eur Respir J. 2004. 23:813–817.
56. Armstrong JJ, Leigh MS, Wlaton ID. In vitro size and shape measurement of the human upper airway using endoscopic long-range optical coherence tomography. Opt Express. 2003. 11:1817–1826.
57. Niimi A, Matsumoto H, Amitani R, Nakano Y, Sakai H, Takemura M, et al. Effect of short-term treatment with inhaled corticosteroid on airway wall thickening in asthma. Am J Med. 2004. 116:725–731.
58. James A, King G. The computed tomographic scan: a new tool to monitor asthma treatment? Am J Med. 2004. 116:775–777.
59. Tanaka H, Yamada G, Saikai T, Hashimoto M, Tanaka S, Suzuki K, et al. Increased airway vascularity in newly diagnosed asthma using a high-magnification bronchovideoscope. Am J Respir Crit Care Med. 2003. 168:1495–1499.
60. Oshita Y, Koga T, Kamimura T, Matsuo K, Rikimaru T, Aizawa H. Increased circulating 92 kDa matrix metalloproteinase (MMP-9) activity in exacerbations of asthma. Thorax. 2003. 58:757–760.
61. James A. Airway remodeling in asthma. Curr Opin Pulm Med. 2005. 11:1–6.
62. Fahy JV, Corry DB, Boushey HA. Airway inflammation and remodeling in asthma. Curr Opin Pulm Med. 2000. 6:15–20.