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Korean J Hematol.  2005 Sep;40(3):197-200. 10.5045/kjh.2005.40.3.197.

A Pediatric Case with CMV Gastroenteritis after Donor Leukocyte Infusion

Affiliations
  • 1Department of Pediatrics, Ajou University School of Medicine, Suwon, Korea. pedpje@ajou.ac.kr
  • 2Department of Surgery, Ajou University School of Medicine, Suwon, Korea.
  • 3Department of Internal Medicine, Ajou University School of Medicine, Suwon, Korea.

Abstract

There haves been few reports of cytomegalovirus (CMV) gastroenteritis following allogeneic stem cell transplantation, especially in pediatric cases. Herein, we report a case of CMV gastroenteritis in a 10-year-old boy with relapsed juvenile myelomonocytic leukemia who had undergone a donor leukocyte infusion. He presented with a skin rash, diarrhea and abdominal pain following a donor leukocyte infusion. Cramping abdominal pain persisted, even after treatment of the acute graft-versus-host disease. Therefore, gastroduodenoscopy and a gastric mucosal biopsy were performed, after which CMV gastroenteritis was diagnosed. The boy recovered after treatment with ganciclovir and intravenous immunoglobulin.

Keyword

CMV gastroenteritis; GVHD; Donor leukocyte infusion

MeSH Terms

Abdominal Pain
Biopsy
Child
Cytomegalovirus
Diarrhea
Exanthema
Ganciclovir
Gastroenteritis*
Graft vs Host Disease
Humans
Immunoglobulins
Leukemia, Myelomonocytic, Juvenile
Leukocytes*
Male
Muscle Cramp
Stem Cell Transplantation
Tissue Donors*
Ganciclovir
Immunoglobulins
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