Hypercalciuria and Hyperuricosuria in Adults with Microscopic Hematuria

Ryu, Jun Ho; Won, Young Woong; Yun, Yeo Wook; Lee, Dong Kyu; Han, Sang Woong; Kim, Ho Jung

Abstract

PURPOSE
We investigated the prevalence of hypercalciuria and hyperuricosuria in adults with microscopic hematuria and whether specific underlying diseases were associated with it. METHODS: A total of 36 patients with microscopic hematuria were divided into hypercalciuria or normocalciuria and hypercalciuria or normouricosuria and compared between groups in their clinical characteristics and laboratory findings. RESULTS: Of the 36 patients, 27 patients (75%) had normocalciuria but 9 (25%) had hypercalciuria. Twenty-eight patients (78%) had normouricosuria but 8(22%) had hyperuricosuria. All 8 patients in the hyperuricosuric group were male but 6 were male and 3 female in the hypercalciuric group. Other basal parameters and clinical characteristics were comparable between hypercalciuric and normocalciuric groups as well as between hyperuricosuric and normouricosuric groups except for significantly higher proteinuria in the latter. Underlying or associated diseases were hypertension (11), nephrolithiasis (5), simple renal cysts (3), hepatitis B carrier (3), diabetes mellitus (2), poststreptococcal glomerulonephritis (1), and membranous nephropathy (1). The degrees of calciuria and uricosuria were not different between patients with or without specific underlying or associated diseases but relative hypercalciuria in diabetic patients and hyperuricosuria in hepatitis B carriers were noted. CONCLUSION: We found a high prevalence of hypercalciuria and hyperuricosuria in adults with microscopic hematuria. In view of relatively higher proteinuria in hyperuricosuric patients in addition to some differences in clinical characteristics of patients with hypercalciuria or hyperuricosuria, a simple cost- effective examination of the degree of calciuria and uricosuria would be helpful in the clinical evaluation of microscopic hematuria.