Korean J Physiol Pharmacol.
2003 Feb;7(1):1-3.
Regulation of [3H]Norepinephrine Release by Opioids in Human Cerebral Cortex
- Affiliations
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- 1Department of Pharmacology, Chonbuk National University Medical School, Chonju, Chonbuk 561-180, Korea. keewon@moak.chon buk.ac.kr
- 2Department of Neurology, Chonbuk National University Medical School, Chonju, Chonbuk 561-180, Korea.
- 3Department of Neurosurgery and Institute for Medical Sciences, Chonbuk National University Medical School, Chonju, Chonbuk 561-180, Korea.
Abstract
- To investigate the receptors mediating the regulation of norepinephrine (NE) release in human cerebral cortex slices, we examined the effects of opioid agonists for mu-, delta-, and kappa -receptors on the high potassium (15 mM) -evoked release of [3H]NE. [3H]NE release induced by high potassium was calcium-dependent and tetrodotoxin-sensitive. [D-Pen2, D-Pen5]enkephalin (DPDPE) and deltorphin II (Delt II) inhibited the stimulated release of norepinephrine in a dose-dependent manner. However, Tyr-D-Ala-Gly- (Me) Phe-Gly-ol and U69, 593 did not influence the NE release. Inhibitory effect of DPDPE and Delt-II was antagonized by naloxone, naltrindole, 7-benzylidenaltrexone and naltriben. These results suggest that both delta 1 and delta 2 receptors are involved in regulation of NE release in human cerebral cortex.
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