Korean J Nucl Med.
2003 Jun;37(3):162-170.
Developing a Korean Standard Brain Atlas on the basis of Statistical and Probabilistic Approach and Visualization tool for Functional image analysis
- Affiliations
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- 1Department of Biomedical Engineering, Hanyang University, Seoul, Korea. sunkim@hanyang.ac.kr
- 2Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Korea.
- 3Department of Psychiatry, Seoul National University College of Medicine, Seoul, Korea.
- 4Department of Psychiatry, Yonsei University College of Medicine, Seoul, Korea.
Abstract
- The probabilistic anatomical maps are used to localize the functional neuro-images and morphological variability. The quantitative indicator is very important to inquire the anatomical position of an activated region because functional image data has the low-resolution nature and no inherent anatomical information. Although previously developed MNI probabilistic anatomical map was enough to localize the data, it was not suitable for the Korean brains because of the morphological difference between Occidental and Oriental. In this study, we develop a probabilistic anatomical map for Korean normal brain. Normal 75 brains of T1-weighted spoiled gradient echo magnetic resonance images were acquired on a 1.5-T GESIGNA scanner. Then, a standard brain is selected in the group through a clinician searches a brain of the average property in the Talairach coordinate system. With the standard brain, an anatomist delineates 89 regions of interest (ROI) parcellating cortical and subcortical areas. The parcellated ROIs of the standard are warped and overlapped into each brain by maximizing intensity similarity. And every brain is automatically labeled with the registered ROIs. Each of the same-labeled region is linearly normalize to the standard brain, and the occurrence of each region is counted. Finally, 89 probabilistic ROI volumes are generated. This paper presents a probabilistic anatomical map for localizing the functional and structural analysis of Korean normal brain. In the future, we'll develop the group specific probabilistic anatomical maps of OCD and schizophrenia disease.
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