Korean J Nephrol.  2006 Jul;25(4):635-639.

A Case about Use of Mycophenolate Mofetil in Acute Renal Failure Associated with Lupus Nephritis

• Park MJ
• Kim HJ
• Lee HM
• Oh JS
• Hwang HC
• Im DH
• Oh HJ
• Park YK
• Shin YH
• Kim JK

Abstract

Mycophenolate mofetil (MMF) is a immunosuppressive agent increasingly used in organ transplantation and autoimmune disease. We report a case about use of MMF in SLE patient with rapidly worsening renal function. A 24-year old female was admitted due to 1-week history of generalized edema. Despite use of diuretics and conventional supported care, generalized edema was more aggravated and serum creatinine was elevated up to 5.2 mg/dL. Ten days after the initial admission, we started hemodialysis. After hemodialysis, improvement of generalized edema was achieved. Eighteen days after initial hemodialysis, we started corticosteroids and MMF because she shows persistent heavy proteinuria and oliguria. After use of corticosteroids and MMF, clinical improvement of renal complication was achieved in this patient. About 6 weeks later, we could discontinue hemodialysis. On two year follow up duration, she shows good renal function and no evidence of lupus flare-up signs. We suggest MMF is one of therapeutic options for patients with severe lupus nephritis, especially those refractory or intolerant to conventional cytotoxic agents.

Keyword

Systemic lupus erythematosus (SLE); Lupus nephritis; Mycophenolate mofetil

MeSH Terms

Acute Kidney Injury*
Adrenal Cortex Hormones
Autoimmune Diseases
Creatinine
Cytotoxins
Diuretics
Edema
Female
Follow-Up Studies
Humans
Lupus Nephritis*
Oliguria
Organ Transplantation
Proteinuria
Renal Dialysis
Transplants
Young Adult
Adrenal Cortex Hormones
Creatinine
Cytotoxins
Diuretics