Mycobiology.  2005 Sep;33(3):142-146. 10.4489/MYCO.2005.33.3.142.

Production of Antihypertensive Angiotensin I-Converting Enzyme Inhibitor from Malassezia pachydermatis G-14

• Jeong SC
• Kim JH
• Kim NM
• Lee JS

• KMID: 1596521
• DOI: http://doi.org/10.4489/MYCO.2005.33.3.142

Abstract

To produce a novel antihypertensive angiotensin I-converting enzyme (ACE) inhibitor from yeast, a yeast isolate, designated G-14 showing the highest ACE inhibitory activity was obtained and identified as Malassezia pachydermatis based on morphological, biochemical and cultural characteristics. The maximal extracellular ACE inhibitor production was obtained from M. pachydermatis G-14 when the strain was cultured in YEPD medium containing 0.5% yeast extract, 3.0% peptone and 2.0% glucose at 30degrees C for 24 h and the final ACE inhibitory activity was 48.9% under the above condition.

Keyword

Angiotensin I-converting enzyme inhibitor; Antihypertensive; Malassezia pachydermatis

MeSH Terms

Angiotensins*
Cultural Characteristics
Glucose
Malassezia*
Peptidyl-Dipeptidase A*
Peptones
Yeasts
Angiotensins
Glucose
Peptidyl-Dipeptidase A
Peptones