Korean J Obstet Gynecol.  2005 Jun;48(6):1390-1401.

Pathophysiology and Treatment Guidelines of Dysfunctional Uterine Bleeding

• Lee KS

Abstract

Dysfunctional uterine bleeding (DUB) is the major cause of heavy menstrual bleeding during reproductive years and impacts on women's health both medically and socially. The pathophysiology of DUB is largely unknown but occurs in both ovulatory and anovulatory menstrual cycles. Medical treatments include tranexamic acid, nonsteroidal antiinflammatory drugs, combined oral contraceptives, progesterone, danazol, and GnRH analogue. Surgical treatments include endometrial ablation and hysterectomy. Since none of the treatments for DUB is superior to one of the others, and since all treatments have their advantages and disadvantages, counselling and management of patients with DUB should incorporate medical approach, levonorgestrel releasing IUD, endometrial ablation and hysterectomy.

Keyword

Dysfunctional uterine bleeding; Pathophysiology; Treatment

MeSH Terms

Contraceptives, Oral, Combined
Danazol
Endometrial Ablation Techniques
Female
Gonadotropin-Releasing Hormone
Hemorrhage
Humans
Hysterectomy
Levonorgestrel
Menstrual Cycle
Metrorrhagia*
Progesterone
Tranexamic Acid
Women's Health
Contraceptives, Oral, Combined
Danazol
Gonadotropin-Releasing Hormone
Levonorgestrel
Progesterone
Tranexamic Acid