J Korean Rheum Assoc.  2005 Jun;12(2):143-148.

A Case of Scleroderma Presented with Malignant Lymphoma of Breast

• Choi SJ
• Rho YH
• Lee YH
• Ji JD
• Song GG
• Kim A

Abstract

We report a patient with scleroderma who had the unusual development of an anaplastic large/null cell malignant lymphoma of her breast at the time of diagnosis of scleroderma. It is well known that patients with scleroderma have malignant neoplasms such as lung cancer, breast cancer, and lymphoproliferative diseases more frequently than normal population. Although it is not well known about disease process of underlying cancer in patients with scleroderma, there must be some possible explanations. In brief, one disease may increase the risk of the other as a direct complication or as a result of the treatment given. Alternatively, the two disorders may share common risk factors. So it seems very important to emphasize that associated malignancy might be validated properly on rapidly developing scleroderma.

Keyword

Scleroderma; Lymphoma; Cancer

MeSH Terms

Breast Neoplasms
Breast*
Diagnosis
Humans
Lung Neoplasms
Lymphoma*
Risk Factors