Korean J Asthma Allergy Clin Immunol.  2006 Dec;26(4):314-317.

Two Cases of Methylenediphenyl Isocyanate-induced Asthma Developed in the Molding Lining of Automobile Industry

Abstract

Since isocyanate-induced occupational asthma (OA) was first reported about 50 years ago, the first case of methylenediphenyl isocyanate (MDI)-induced OA was reported in 1973. Although toluene diisocyanate (TDI)-induced OA is the most common OA, MDI-induced asthma has been very rarely reported in Korea. Here we report two cases of MDI- induced OA developed in the molding lining of automobile industry. Two patients who had worked at the molding lining using MDI for several years presented with cough and dyspnea. The metacholine bronchial provocation tests of two patients were positive (PC(20) : 1.51 mg/mL and PC(20) : 1.28 mg/mL, respectively). The bronchial provocation tests with MDI showed early response. MDI aerosol was generated by heating MDI to 100degrees C with heat block. Skin prick tests were all negative to common inhalent allergens and MDI. The level of serum total IgE was within the normal range. They are now well-controlled state with persistent medication and changes of working place in the same company.

MeSH Terms

Allergens
Asthma*
Asthma, Occupational
Automobiles*
Bronchial Provocation Tests
Cough
Dyspnea
Fungi*
Heating
Hot Temperature
Humans
Immunoglobulin E
Korea
Reference Values
Skin
Toluene 2,4-Diisocyanate
Allergens
Immunoglobulin E
Toluene 2,4-Diisocyanate