J Korean Orthop Res Soc.  2006 Apr;9(1):65-75.

Effect of Amniotic Membrane Transplantation and Heparin on Tissue Adhesion in Flexor Tenorrhaphy of Chicken

• Kim SS
• Lee MJ
• Chung IK
• Ko MS

Abstract

PURPOSE
The role of the amniotic membrane with or without heparin was investigated with regard to the prevention of adhesion formation following flexor tenorrhaphy of chicken.
MATERIALS AND METHODS
We classified twelve chickens into four groups of three chickens. In group A, the flexor tendon was partially cut and the tendon was repaired. In group B, The repaired tendon was covered with heparin. In group C, the repaired tendon was covered with amniotic membrane. In group D, the repaired tendon was covered with amniotic membrane and heparin. Histologic and gross findings of the repaired tendon were evaluated at postoperative 3, 6 and 9 weeks.
RESULTS
In group D, there were less inflammatory cell infiltration and fibroblasts proliferation in all stages. At postoperative 9 weeks of all groups, there were less inflammation and fibroblasts proliferation than those in postoperative 3 and 6 weeks.
CONCLUSION
The use of amniotic membrane transplantation and heparin is effective in the prevention of inflammation and adhesion formation following flexor tenorrhaphy of chicken.

Keyword

Amniotic membrane; Heparin; Tenorrhaphy

MeSH Terms

Amnion*
Chickens*
Fibroblasts
Heparin*
Inflammation
Tendons
Tissue Adhesions*
Heparin