J Korean Soc Pediatr Endocrinol.  2004 Dec;9(2):204-207.

Two Cases of Transient Neonatal Diabetes Mellitus in Twin Brothers

Abstract

Neonatal diabetes mellitus (NDM) is defined as hyperglycemia that presents clinical symptoms within the first month of life and requires insulin therapy to maintain euglycemia. The diabetic condition may be transient, permanent, or transient with recurrence later in life. NDM is a rare clinical disorder. Three cases of NDM have been reported in Korea so far. We experienced two cases of NDM in twin brothers who were born with small for gestational ages. Their HLA typings were DR9 and DR14, and insulin autoantibody, islet cell antibody, GAD-reactive autoantibody, and insulin receptor antibody were not found. The genetic analysis with polymorphic DNA markers for chromosome 6 indicated paternal uniparental isodisomy.

Keyword

Neonatal diabetes mellitus; Twin; Chromosome6; Uniparental disomy

MeSH Terms

Chromosomes, Human, Pair 6
Diabetes Mellitus*
Genetic Markers
Gestational Age
Histocompatibility Testing
Humans
Hyperglycemia
Insulin
Islets of Langerhans
Korea
Receptor, Insulin
Recurrence
Siblings*
Twins*
Uniparental Disomy
Genetic Markers
Insulin
Receptor, Insulin
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