Korean J Fertil Steril.  2002 Dec;29(4):311-316.

Association Study of the Relationship between Endometriosis and Polymorphism of p53 Codon 72

• Hur SE
• Shim SS
• Lee KS
• Moon HS
• Yu HK
• Chung HW

Abstract

OBJECTIVE
The present study was performed to evaluate the association of p53 codon 72 polymorphism and endometriosis. MATERIALS AND
METHODS
We investigate 74 women who were operated for endometriosis and 93 women who had no endometriotic lesion proved by operation. Polymerase chain reaction was used to detect p53 codon polymorphisms. Result: We have found no significant difference between endometriosis and control group in the p53 codon polymorphism. The respective proportion of arginine homozygotes, heterozygotes and proline homozygotes in endometriosis group were 18.9%, 62.2% and 18.9%, respectively, and were 12.9%, 75.2% and 11.9%, respective in the group without endometriosis.
CONCLUSION
Endometriosis is not associated with p53 polymorphism in Korean endometriosis patients.

Keyword

Endometriosis; p53; Polymorphism; Arginine; Proline

MeSH Terms

Arginine
Codon*
Endometriosis*
Female
Heterozygote
Homozygote
Humans
Polymerase Chain Reaction
Proline
Arginine
Codon
Proline